Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.40 |
| ▸ | HTR1D | P28221 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4135876 | 0.87 | GRIN2B (0.41) | GRIN2BHTR1DBACE1HTR1AHTR7 | |
| SCHEMBL4148823 | 0.84 | HTR2A (0.41) | HTR1DCYP2D6BACE1CYP1A2CYP11B1 | |
| SCHEMBL4145248 | 0.83 | GRIN2B (0.51) | GRIN2BHTR1DBACE1HTR1AHTR7 | |
| SCHEMBL4140221 | 0.83 | MCHR1 (0.38) | MCHR1KCNH2 | |
| SCHEMBL4148545 | 0.82 | HTR1A (0.44) | GRIN2BHTR1DHTR1AHTR7CYP11B1 | |
| SCHEMBL4147479 | 0.82 | FYN (0.44) | GRIN2BHTR1DHTR1AHTR7CYP1A2 | |
| SCHEMBL4136629 | 0.82 | OPRM1 (0.44) | GRIN2BHTR1DHTR1AHTR7OPRM1 | |
| SCHEMBL4132535 | 0.82 | OPRM1 (0.44) | GRIN2BHTR1DHTR1AHTR7OPRM1 | |
| SCHEMBL4141143 | 0.82 | OPRM1 (0.44) | GRIN2BHTR1DHTR1AHTR7OPRM1 | |
| SCHEMBL4130700 | 0.82 | ALDH1A1 (0.39) | GRIN2BHTR1DCYP2D6OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090163482-A1 | TETRALINES ANTAGONISTS OF THE H-3 RECEPTOR | MCHARDY STANTON FURST | 2009-06-25 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163482-A1 | TETRALINES ANTAGONISTS OF THE H-3 RECEPTOR | HRH3, HRH4, HRH1 | GRIN2B 86/4885MCHR1 287/4885HTR1D 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.