Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 1.00 |
| ▸ | CA1 | P00915 | 4/20 | 0.57 |
| ▸ | CA2 | P00918 | 4/20 | 0.57 |
| ▸ | CDC25B | P30305 | 3/20 | 0.55 |
| ▸ | PTPRC | P08575 | 1/20 | 0.55 |
| ▸ | PTPRF | P10586 | 1/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
| ▸ | CDC25A | P30304 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | APAF1 | O14727 | 1/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL413750 | 0.78 | CYP19A1 (0.63) | CYP19A1CDC25BPTPN1CDC25ASMN1; SMN2 | |
| SCHEMBL30704429 | 0.77 | RAB9A (0.67) | CYP19A1CDC25BPTPRCPTPRFPTPN1 | |
| SCHEMBL15690558 | 0.77 | CYP19A1 (0.62) | CYP19A1CA1CA2CDC25BPTPRC | |
| SCHEMBL412798 | 0.76 | CYP19A1 (0.61) | CYP19A1CA1CA2SMN1; SMN2MEN1 | |
| SCHEMBL16938319 | 0.74 | CYP19A1 (0.59) | CYP19A1CA1CA2CDC25BPTPRC | |
| SCHEMBL18415526 | 0.73 | CA1 (1.00) | CYP19A1CA1CA2SMN1; SMN2MEN1 | |
| SCHEMBL30704447 | 0.72 | GAPDH (0.63) | CYP19A1CA1CA2CDC25BPTPRC | |
| SCHEMBL11412192 | 0.72 | CYP19A1 (0.56) | CYP19A1CDC25BPTPRCPTPRFPTPN1 | |
| SCHEMBL15514574 | 0.71 | CDC25B (0.55) | CYP19A1CDC25BPTPRCPTPRFPTPN1 | |
| SCHEMBL13934091 | 0.71 | CA1 (0.87) | CYP19A1CA1CA2SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120021519-A1 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2012-01-26 | — | — | US | disclosed |
| WO-2010033906-A2 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-03-25 | — | — | WO | disclosed |