Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 8/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.40 |
| ▸ | MEN1 | O00255 | 6/20 | 0.40 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | APAF1 | O14727 | 2/20 | 0.40 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.40 |
| ▸ | TDP2 | O95551 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL413751 | 0.78 | CYP19A1 (1.00) | CYP19A1MAPTSMN1; SMN2MAPK1KMT2A | |
| SCHEMBL412797 | 0.77 | ALDH1A1 (0.38) | CYP19A1MAPTSMN1; SMN2MAPK1KDM4E | |
| SCHEMBL19953389 | 0.74 | CYP19A1 (0.53) | CYP19A1MAPTSMN1; SMN2MAPK1PKM | |
| SCHEMBL3394005 | 0.69 | ALOX5 (0.62) | MAPTKMT2AMEN1KDM4EHTT | |
| SCHEMBL14840537 | 0.69 | TTR (0.51) | MAPTSMN1; SMN2MAPK1PKMKMT2A | |
| SCHEMBL28414899 | 0.68 | PLK1 (0.48) | MAPTALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL5373332 | 0.68 | L3MBTL1 (0.48) | CYP19A1MAPTPKMKMT2AMEN1 | |
| SCHEMBL26436210 | 0.68 | MAPK13 (0.57) | MAPTMAPK1KMT2AMEN1HPGD | |
| SCHEMBL1705430 | 0.67 | EGFR (0.75) | MAPTHKDC1NOX4ALDH1A1TDP1 | |
| SCHEMBL12679379 | 0.67 | MEN1 (0.48) | MAPTSMN1; SMN2KMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120021519-A1 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2012-01-26 | — | — | US | disclosed |
| WO-2010033906-A2 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-03-25 | — | — | WO | disclosed |