Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | PPIA | P62937 | 1/20 | 0.39 |
| ▸ | SCD | O00767 | 3/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29956983 | 0.77 | POLB (0.53) | ALDH1A1POLBPPIARAB9ANPC1 | |
| SCHEMBL29952615 | 0.74 | POLB (0.56) | ALDH1A1POLBPPIARAB9ANPC1 | |
| SCHEMBL18640773 | 0.68 | POLB (0.65) | ALDH1A1POLBRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL18001993 | 0.68 | MAPK14 (0.52) | ALDH1A1RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL5891015 | 0.68 | ALDH1A1 (0.38) | ALDH1A1POLBRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL1244152 | 0.67 | ALDH1A1 (0.55) | ALDH1A1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL14398672 | 0.67 | ALDH1A1 (0.57) | ALDH1A1LMNA | |
| SCHEMBL23608334 | 0.66 | POLB (0.51) | ALDH1A1POLBRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL8970761 | 0.66 | POLB (0.55) | ALDH1A1POLBRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL31307412 | 0.66 | POLB (0.51) | ALDH1A1POLBRAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227565-A1 | Biphenyl Vasopressin Agonists | WYETH (US) | 2009-09-10 | — | — | US | disclosed |
| US-7465722-B2 | Biphenyl vasopressin agonists | WYETH (US) | 2008-12-16 | — | — | US | disclosed |
| US-7329653-B2 | Cyclohexylphenyl vasopressin agonists | WYETH (US) | 2008-02-12 | — | — | US | disclosed |
| EP-1381608-B1 | CYCLOHEXYLPHENYL VASOPRESSIN AGONISTS | WYETH CORP (US) | 2007-10-10 | — | — | EP | disclosed |
| US-7223752-B2 | Biphenyl vasopressin agonists | WYETH (US) | 2007-05-29 | — | — | US | disclosed |
| EP-1381370-B1 | N-BIPHENYLCARBONYL- AND N-PHENYLPYRIDYLCARBONYL SUBSTITUTED BI- AND TRICYCLIC AZEPINES AND DIAZEPINES AS VASOPRESSING AGONISTS | WYETH CORP (US) | 2007-03-07 | — | — | EP | disclosed |
| US-20060276456-A1 | Biphenyl vasopressin agonists | WYETH (US) | 2006-12-07 | — | — | US | disclosed |
| US-20060183734-A1 | Cyclohexylphenyl vasopressin agonists | WYETH (US) | 2006-08-17 | — | — | US | disclosed |
| US-7053083-B2 | Cyclohexylphenyl vasopressin agonists | WYETH (US) | 2006-05-30 | — | — | US | disclosed |
| US-6903091-B2 | Biphenyl vasopressin agonists | WYETH (US) | 2005-06-07 | — | — | US | disclosed |
| US-20050075328-A1 | Biphenyl vasopressin agonists | WYETH (US) | 2005-04-07 | — | — | US | disclosed |
| EP-1381608-A1 | CYCLOHEXYLPHENYL VASOPRESSIN AGONISTS | Wyeth (US) | 2004-01-21 | — | — | EP | disclosed |
| EP-1381370-A1 | N-BIPHENYLCARBONYL- AND N-PHENYLPYRIDYLCARBONYL SUBSTITUTED BI- AND TRICYCLIC AZEPINES AND DIAZEPINES AS VASOPRESSING AGONISTS | Wyeth (US) | 2004-01-21 | — | — | EP | disclosed |
| US-20030018024-A1 | Biphenyl vasopressin agonists | WYETH | 2003-01-23 | — | — | US | disclosed |
| US-20020198191-A1 | Medicine for inducing temporary delay of urination or treatment of disorders of diabetes insipidus, nocturnal enuresis, nocturia, urinary incontinence, or bleeding and coagulation disorders | WYETH (US) | 2002-12-26 | — | — | US | disclosed |
| WO-2002083685-A1 | CYCLOHEXYLPHENYL VASOPRESSIN AGONISTS | WYETH (US) | 2002-10-24 | — | — | WO | disclosed |
| WO-2002083145-A1 | N-BIPHENYLCARBONYL- AND N-PHENYLPYRIDYLCARBONYL SUBSTITUTED BI- AND TRICYCLIC AZEPINES AND DIAZEPINES AS VASOPRESSING AGONISTS | WYETH (US) | 2002-10-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227565-A1 | Biphenyl Vasopressin Agonists | AVPR2, AVPR1B, SSTR3 | ALDH1A1 1977/4885POLB 4494/4885PPIA 4755/4885 |
| US-20060276456-A1 | Biphenyl vasopressin agonists | AVPR2, AVPR1B, SSTR3 | ALDH1A1 1977/4885POLB 4494/4885PPIA 4755/4885 |
| US-20020198191-A1 | Medicine for inducing temporary delay of urination or treatment of disorders of diabetes insipidus, nocturnal enuresis, nocturia, urinary incontinence, or bleeding and coagulation disorders | F2, AVPR2, SHBG | ALDH1A1 1408/4885POLB 4023/4885PPIA 320/4885 |
| US-20060183734-A1 | Cyclohexylphenyl vasopressin agonists | AVPR2, AVPR1A, AVPR1B | ALDH1A1 2998/4885POLB 4188/4885PPIA 898/4885 |
| US-20030018024-A1 | Biphenyl vasopressin agonists | AVPR2, AVPR1B, AVPR1A | ALDH1A1 1159/4885POLB 4340/4885PPIA 4788/4885 |
| US-20050075328-A1 | Biphenyl vasopressin agonists | AVPR2, AVPR1B, SSTR3 | ALDH1A1 1977/4885POLB 4494/4885PPIA 4755/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.