Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 3/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.64 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.64 |
| ▸ | HTR1B | P28222 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | DRD5 | P21918 | 1/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29904797 | 0.87 | HTR7 (1.00) | HTR7ALDH1A1KDM4ESMN1; SMN2ADRB2 | |
| SCHEMBL11580161 | 0.83 | HTR7 (0.51) | HTR7ALDH1A1KDM4ESMN1; SMN2ADRB2 | |
| SCHEMBL5959899 | 0.82 | TTR (0.72) | HTR7ALDH1A1KDM4ESMN1; SMN2TP53 | |
| SCHEMBL8415073 | 0.79 | HTR7 (0.84) | HTR7ALDH1A1KDM4ESMN1; SMN2ADRB2 | |
| Hydrochloric Acid SCHEMBL11621730 | 0.78 | HTR7 (0.81) | HTR7ALDH1A1KDM4ESMN1; SMN2ADRB2 | |
| SCHEMBL11023742 | 0.78 | KDM4E (0.86) | HTR7ALDH1A1KDM4ESMN1; SMN2ADRB2 | |
| Benzene SCHEMBL27860903 | 0.77 | TTR (0.62) | HTR7ADRB2CYP11B1CYP11B2TP53 | |
| SCHEMBL7222905 | 0.77 | KDM4E (0.77) | HTR7ALDH1A1KDM4ESMN1; SMN2ADRB2 | |
| SCHEMBL5585586 | 0.76 | HTR7 (0.69) | HTR7ALDH1A1KDM4ESMN1; SMN2ADRB2 | |
| SCHEMBL11020807 | 0.76 | KDM4E (0.83) | HTR7ALDH1A1KDM4ESMN1; SMN2ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054467-A1 | Pyrrolo Pyrimidines as Agents for the Inhibition of Cystein Proteases | BETSCHART CLAUDIA | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054467-A1 | Pyrrolo Pyrimidines as Agents for the Inhibition of Cystein Proteases | CTSK, CTSS, CTSZ | HTR7 4016/4885ALDH1A1 2931/4885KDM4E 2382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.