Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 7/20 | 0.83 |
| ▸ | AVPR2 | P30518 | 6/20 | 0.83 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.83 |
| ▸ | HTR1A | P08908 | 2/20 | 0.83 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.83 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.83 |
| ▸ | AVPR1B | P47901 | 2/20 | 0.83 |
| ▸ | OXTR | P30559 | 1/20 | 0.83 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.83 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.83 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.67 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.67 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.67 |
| ▸ | HTR2C | P28335 | 1/20 | 0.67 |
| ▸ | HRH1 | P35367 | 1/20 | 0.67 |
| ▸ | GLP1R | P43220 | 1/20 | 0.67 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.67 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.67 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7345732 | 0.92 | AVPR2 (0.70) | AVPR1AAVPR2ABCB11HTR1ACHRM1 | |
| SCHEMBL7353622 | 0.92 | AVPR1A (0.76) | AVPR1AAVPR2ABCB11HTR1ACHRM1 | |
| SCHEMBL7344966 | 0.92 | AVPR1A (0.76) | AVPR1AAVPR2ABCB11HTR1ACHRM1 | |
| SCHEMBL4142479 | 0.92 | AVPR2 (0.76) | AVPR1AAVPR2ABCB11HTR1ACHRM1 | |
| Mozavaptan SCHEMBL15084884 | 0.91 | AVPR1A (1.00) | AVPR1AAVPR2ABCB11HTR1ACHRM1 | |
| Mozavaptan SCHEMBL29388889 | 0.91 | AVPR1A (1.00) | AVPR1AAVPR2ABCB11HTR1ACHRM1 | |
| Mozavaptan SCHEMBL1649322 | 0.91 | AVPR1A (1.00) | AVPR1AAVPR2ABCB11HTR1ACHRM1 | |
| SCHEMBL7359052 | 0.90 | AVPR2 (0.80) | AVPR1AAVPR2ABCB11HTR1ACHRM1 | |
| SCHEMBL7349794 | 0.90 | AVPR1A (0.73) | AVPR1AAVPR2ABCB11HTR1ACHRM1 | |
| Mozavaptan SCHEMBL1111095 | 0.90 | AVPR1A (0.98) | AVPR1AAVPR2ABCB11HTR1ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001054698-A1 | METHOD FOR PREVENTING OR TREATING POSTOPERATIVE ILEUS | WARNER-LAMBERT COMPANY (US) | 2001-08-02 | — | — | WO | claimed |
| US-5753677-A | Benzoheterocyclic compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-05-19 | — | — | US | claimed |
| EP-0450097-B1 | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMA CO LTD (JP) | 1996-04-24 | — | — | EP | claimed |
| WO-1991005549-A1 | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-05-02 | — | — | WO | claimed |
| US-10232044-B2 | Controlled release aural pressure modulator compositions and methods for the treatment of OTIC disorders | OTONOMY, INC. (US) | 2019-03-19 | — | — | US | disclosed |
| US-20090239844-A1 | ACE INHIBITOR-VASOPRESSIN ANTAGONIST COMBINATIONS | ASTELLAS PHARMA, INC. | 2009-09-24 | — | — | US | disclosed |
| US-7192951-B2 | Treatment of congestive heart failure | ASTELLAS PHARMA INC. (JP) | 2007-03-20 | — | — | US | disclosed |
| EP-1253945-B1 | ACE INHIBITOR-VASOPRESSIN ANTAGONIST COMBINATIONS | ASTELLAS PHARMA INC (JP) | 2006-10-04 | — | — | EP | disclosed |
| EP-1280555-B8 | PHARMACEUTICAL COMPOSITION COMPRISING FUROSEMIDE AND CONIVAPTAN FOR THE TREATMENT OF CONGESTIVE HEART FAILURE | ASTELLAS PHARMA INC (JP) | 2006-06-28 | — | — | EP | disclosed |
| US-20050245506-A1 | Treatment of congestive heart failure | ASTELLAS IRELAND CO., LTD. (IE) | 2005-11-03 | — | — | US | disclosed |
| US-20050234043-A1 | ACE inhibitor-vasopressin antagonist combinations | ASTELLAS PHARMA INC. (JP) | 2005-10-20 | — | — | US | disclosed |
| US-20040176354-A1 | Treatment of congestive heart failure | ASTELLAS PHARMA INC. (JP) | 2004-09-09 | — | — | US | disclosed |
| EP-1195166-A2 | Use of a vasopressin antagonist such as conivaptan in the manufacture of a medicament for treating pulmonary hypertension | WARNER-LAMBERT COMPANY (US) | 2002-04-10 | — | — | EP | disclosed |
| WO-2001082920-A2 | TREATMENT OF CONGESTIVE HEART FAILURE WITH A COMPOSITION COMPRISING A DIURETIC AGENT AND A VASOPRESSIN ANTAGONIST | WARNER-LAMBERT COMPANY (US) | 2001-11-08 | — | — | WO | disclosed |
| WO-2001054677-A2 | ACE INHIBITOR-VASOPRESSIN ANTAGONIST COMBINATIONS | WARNER-LAMBERT COMPANY (US) | 2001-08-02 | — | — | WO | disclosed |
| US-5985869-A | USEFUL AS VASODILATORS, HYPOTENSIVE AGENTS, WATER DIURETICS, PLATELET AGGLUTINATION INHIBITORS | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1999-11-16 | — | — | US | disclosed |
| US-5753677-A | Benzoheterocyclic compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| US-5559230-A | VASOPRESSIN ANTAGONISTS, QUINOLINES, BENZAZEPINES, VASODILATION, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-09-24 | — | — | US | disclosed |
| EP-0450097-B1 | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMA CO LTD (JP) | 1996-04-24 | — | — | EP | disclosed |
| WO-1991005549-A1 | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234043-A1 | ACE inhibitor-vasopressin antagonist combinations | AVPR2, ACE, AGT | AVPR1A 5/4885AVPR2 1/4885ABCB11 1880/4885 |
| US-10232044-B2 | Controlled release aural pressure modulator compositions and methods for the treatment of OTIC disorders | OTC, MYOC, SLC26A4 | AVPR1A 667/4885AVPR2 460/4885ABCB11 56/4885 |
| US-20090239844-A1 | ACE INHIBITOR-VASOPRESSIN ANTAGONIST COMBINATIONS | AVPR2, ACE, AGT | AVPR1A 5/4885AVPR2 1/4885ABCB11 1880/4885 |
| US-20050245506-A1 | Treatment of congestive heart failure | AVPR2, AVPR1A, NPPA | AVPR1A 2/4885AVPR2 1/4885ABCB11 175/4885 |
| US-20040176354-A1 | Treatment of congestive heart failure | AVPR2, NPPA, REN | AVPR1A 4/4885AVPR2 1/4885ABCB11 175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.