Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 9/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 9/20 | 0.45 |
| ▸ | ACP1 | P24666 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4155177 | 0.88 | PTGDR (0.49) | TPH1MKNK1MKNK2ACP1JAK2 | |
| SCHEMBL4160480 | 0.86 | PDGFRB (0.50) | TPH1MKNK1MKNK2ACP1KDM4E | |
| SCHEMBL4995521 | 0.84 | BRAF (0.53) | MKNK1MKNK2ACP1SIGMAR1KDM4E | |
| SCHEMBL4148108 | 0.80 | FYN (0.41) | TPH1MKNK1MKNK2JAK2ROCK2 | |
| SCHEMBL3645075 | 0.79 | MKNK1 (0.60) | MKNK1MKNK2CLK2GSK3BDYRK1A | |
| SCHEMBL4147501 | 0.79 | CCNT1 (0.46) | MKNK1MKNK2PTGDRCCNT1 | |
| SCHEMBL4139805 | 0.79 | FYN (0.56) | TPH1KDM4EHTTPTGDR | |
| SCHEMBL4161155 | 0.78 | PTGDR (0.51) | MKNK1MKNK2CYP11B1CYP11B2KDM4E | |
| SCHEMBL4142715 | 0.78 | MKNK1 (0.48) | MKNK1MKNK2CYP11B1KDM4EKCNH3 | |
| SCHEMBL4152258 | 0.78 | PIM1 (0.52) | MKNK1MKNK2ROCK2ROCK1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090163515-A1 | Compounds Which Bind to the Active Site of Protein Kinase Enzymes | BIOFOCUS DISCOVERY LTD. | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163515-A1 | Compounds Which Bind to the Active Site of Protein Kinase Enzymes | ROCK1, ROCK2, CIT | TPH1 2806/4885MKNK1 210/4885MKNK2 213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.