Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR | Q13258 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.45 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 2/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | AKT2 | P31751 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4139867 | 0.88 | TPH1 (0.45) | PTGDRKDM4ECYP11B1CYP11B2MKNK2 | |
| SCHEMBL3648927 | 0.81 | CDK2 (0.57) | PTGDRNPC1RAB9AL3MBTL1KDM4E | |
| SCHEMBL1054752 | 0.76 | PIK3CD (0.72) | PIM1JAK2CDK1CDK2GSK3B | |
| SCHEMBL4160480 | 0.74 | PDGFRB (0.50) | RAB9AKDM4EMKNK2MAPK1TPH1 | |
| SCHEMBL3645314 | 0.72 | CDK2 (0.70) | KDM4ECYP11B1CYP11B2CYP17A1CYP19A1 | |
| SCHEMBL4995521 | 0.72 | BRAF (0.53) | PTGDRKDM4EPIM1MKNK2PIM3 | |
| SCHEMBL31065714 | 0.72 | ALDH1A1 (0.42) | NPC1RAB9AL3MBTL1KDM4ECYP11B1 | |
| SCHEMBL27535607 | 0.71 | CYP1A2 (0.58) | NPC1RAB9AL3MBTL1KDM4EMKNK2 | |
| Hydrochloric Acid SCHEMBL9849411 | 0.71 | MKNK1 (0.55) | PTGDRNPC1RAB9AL3MBTL1KDM4E | |
| SCHEMBL16928258 | 0.70 | GBA1 (0.43) | PTGDRNPC1RAB9AL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090163515-A1 | Compounds Which Bind to the Active Site of Protein Kinase Enzymes | BIOFOCUS DISCOVERY LTD. | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163515-A1 | Compounds Which Bind to the Active Site of Protein Kinase Enzymes | ROCK1, ROCK2, CIT | PTGDR 1188/4885NPC1 1679/4885RAB9A 1053/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.