Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 6/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 5/20 | 0.40 |
| ▸ | KDR | P35968 | 5/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4139796 | 0.87 | CYP1A2 (0.47) | PIM1PTGDRMKNK1MKNK2CYP1A2 | |
| SCHEMBL4139867 | 0.78 | TPH1 (0.45) | DYRK1APTGDRMKNK1MKNK2ROCK2 | |
| SCHEMBL1945468 | 0.73 | FYN (0.66) | PIM1DYRK1A | |
| SCHEMBL4139805 | 0.73 | FYN (0.56) | PTGDRCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4147501 | 0.73 | CCNT1 (0.46) | PTGDRMKNK1MKNK2KDR | |
| SCHEMBL4143605 | 0.73 | HIF1A (0.47) | CYP3A4CYP2C9ROCK2ROCK1NAMPT | |
| SCHEMBL1945470 | 0.73 | NAMPT (0.44) | PIM1DYRK1ASYKCYP1A2CYP3A4 | |
| SCHEMBL4148108 | 0.72 | FYN (0.41) | DYRK1APTGDRMKNK1MKNK2MAPT | |
| SCHEMBL4160480 | 0.71 | PDGFRB (0.50) | MKNK1MKNK2FLT1KDRMAPT | |
| SCHEMBL4148649 | 0.69 | PTGDR (0.39) | PTGDRMKNK1MKNK2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090163515-A1 | Compounds Which Bind to the Active Site of Protein Kinase Enzymes | BIOFOCUS DISCOVERY LTD. | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163515-A1 | Compounds Which Bind to the Active Site of Protein Kinase Enzymes | ROCK1, ROCK2, CIT | PIM1 653/4885DYRK1A 1204/4885SYK 441/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.