Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | TPH1 | P17752 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 8/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 8/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | ACP1 | P24666 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4139867 | 0.86 | TPH1 (0.45) | TPH1MKNK1MKNK2KDM4EACP1 | |
| SCHEMBL4161155 | 0.76 | PTGDR (0.51) | MKNK1MKNK2CNR2KDM4ECCNT1 | |
| SCHEMBL4142715 | 0.76 | MKNK1 (0.48) | MKNK1MKNK2CNR2KDM4ECCNT1 | |
| SCHEMBL4148108 | 0.75 | FYN (0.41) | TPH1MKNK1MKNK2KDM4EMAPK1 | |
| SCHEMBL4155177 | 0.74 | PTGDR (0.49) | TPH1MKNK1MKNK2KDM4EMAPK1 | |
| SCHEMBL13894988 | 0.73 | CNR2 (0.44) | PDGFRBPDGFRACNR2KDM4EHTT | |
| SCHEMBL4148649 | 0.72 | PTGDR (0.39) | MKNK1MKNK2CNR2KDM4EMAPK1 | |
| SCHEMBL31065714 | 0.72 | ALDH1A1 (0.42) | TPH1KDM4EMAPK1GAAHTT | |
| SCHEMBL4139805 | 0.72 | FYN (0.56) | TPH1CNR2KDM4EHTTALDH1A1 | |
| SCHEMBL4147501 | 0.72 | CCNT1 (0.46) | MKNK1MKNK2CCNT1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090163515-A1 | Compounds Which Bind to the Active Site of Protein Kinase Enzymes | BIOFOCUS DISCOVERY LTD. | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163515-A1 | Compounds Which Bind to the Active Site of Protein Kinase Enzymes | ROCK1, ROCK2, CIT | PDGFRB 1244/4885PDGFRA 1484/4885TPH1 2806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.