Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 8/20 | 0.42 |
| ▸ | CLK1 | P49759 | 7/20 | 0.42 |
| ▸ | DYRK2 | Q92630 | 7/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 7/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PRKCB | P05771 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30688283 | 0.86 | CRBN (0.50) | DYRK1ACLK1DYRK2DYRK1BCLK4 | |
| SCHEMBL26683994 | 0.86 | CRBN (0.50) | DYRK1ACLK1DYRK2DYRK1BCLK4 | |
| SCHEMBL410875 | 0.77 | CYP3A4 (0.43) | DYRK1ACLK1DYRK2DYRK1BCLK4 | |
| SCHEMBL3785579 | 0.77 | AR (0.48) | DYRK1ACLK1DYRK2DYRK1BCLK4 | |
| SCHEMBL409024 | 0.77 | LMNA (0.44) | DYRK1ACLK1DYRK2DYRK1BCLK4 | |
| SCHEMBL423755 | 0.74 | ALDH1A1 (0.44) | DYRK1ADYRK2DYRK1BTDP1L3MBTL1 | |
| SCHEMBL3780545 | 0.74 | DYRK1A (0.44) | DYRK1ACLK1DYRK2DYRK1BCLK4 | |
| SCHEMBL413327 | 0.73 | L3MBTL1 (0.43) | DYRK1ADYRK2DYRK1BTDP1L3MBTL1 | |
| SCHEMBL410434 | 0.73 | L3MBTL1 (0.45) | DYRK1ACLK1DYRK2DYRK1BCLK4 | |
| SCHEMBL30071473 | 0.72 | QPCT (0.51) | KDM4ECYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408769-A1 | PYRIMIDINE DERIVATIVES USED AS ITK INHIBITORS | Glaxo Group Limited (GB) | 2012-01-25 | — | — | EP | disclosed |
| WO-2010106016-A1 | PYRIMIDINE DERIVATIVES USED AS ITK INHIBITORS | GLAXO GROUP LIMITED (GB) | 2010-09-23 | — | — | WO | disclosed |