Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 4/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | APOB | P04114 | 1/20 | 0.34 |
| ▸ | MTTP | P55157 | 1/20 | 0.34 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.34 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.33 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4148536 | 0.91 | FPR2 (0.39) | HRH3KCNH2HCRTR1PDK1PDK2 | |
| SCHEMBL4148543 | 0.91 | FPR2 (0.39) | HRH3KCNH2HCRTR1PDK1PDK2 | |
| SCHEMBL4664245 | 0.87 | HRH3 (0.34) | HSD17B3HRH3KCNH2HCRTR1PDK1 | |
| SCHEMBL4148990 | 0.85 | HRH3 (0.36) | HRH3KCNH2HCRTR1FAAHASIC3 | |
| SCHEMBL4135556 | 0.84 | CD274 (0.38) | HRH3KCNH2ASIC3 | |
| SCHEMBL4127215 | 0.83 | MCHR1 (0.38) | HSD17B3HRH3KCNH2ASIC3 | |
| SCHEMBL4128118 | 0.83 | PDK1 (0.42) | HRH3KCNH2PDK1PDK2PDK3 | |
| SCHEMBL4127329 | 0.83 | HTR1A (0.42) | HRH3KCNH2ASIC3 | |
| SCHEMBL4131506 | 0.82 | HSD17B3 (0.40) | HSD17B3HRH3KCNH2PDK1PDK2 | |
| SCHEMBL4142012 | 0.82 | PDK1 (0.43) | HSD17B3HRH3PDK1PDK2PDK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090163482-A1 | TETRALINES ANTAGONISTS OF THE H-3 RECEPTOR | MCHARDY STANTON FURST | 2009-06-25 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163482-A1 | TETRALINES ANTAGONISTS OF THE H-3 RECEPTOR | HRH3, HRH4, HRH1 | HSD17B3 398/4885HRH3 1/4885KCNH2 657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.