Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.32 |
| ▸ | FEN1 | P39748 | 2/20 | 0.32 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4144492 | 0.87 | HSD17B3 (0.42) | HRH3KCNH2PDK1PDK2PDK3 | |
| SCHEMBL4135770 | 0.86 | FAAH (0.40) | HRH3TSHRNPSR1HSD17B3FAAH | |
| SCHEMBL4148543 | 0.86 | FPR2 (0.39) | HRH3KCNH2PDK1PDK2PDK3 | |
| SCHEMBL4148536 | 0.86 | FPR2 (0.39) | HRH3KCNH2PDK1PDK2PDK3 | |
| SCHEMBL4139549 | 0.85 | PDK1 (0.38) | HRH3PDK1PDK2PDK3PDK4 | |
| SCHEMBL4148990 | 0.81 | HRH3 (0.36) | HRH3KCNH2HCRTR1FAAHASIC3 | |
| SCHEMBL4135556 | 0.80 | CD274 (0.38) | HRH3KCNH2TSHRLMNAASIC3 | |
| SCHEMBL4127215 | 0.79 | MCHR1 (0.38) | HRH3KCNH2HSD17B3ASIC3MCHR1 | |
| SCHEMBL4128118 | 0.79 | PDK1 (0.42) | HRH3KCNH2PDK1PDK2PDK3 | |
| SCHEMBL4127329 | 0.79 | HTR1A (0.42) | HRH3KCNH2ASIC3MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007749-A2 | TETRALINES ANTAGONISTS OF THE H-3 RECEPTOR | Pfizer Products Inc. (US) | 2008-12-31 | — | — | EP | claimed |
| WO-2007105053-A2 | TETRALINES ANTAGONISTS OF THE H-3 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-09-20 | — | — | WO | claimed |