Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 4/20 | 0.34 |
| ▸ | PRKCA | P17252 | 1/20 | 0.34 |
| ▸ | MMP12 | P39900 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TNKS | O95271 | 1/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4145150 | 1.00 | KCNH2 (0.35) | KCNH2CYP3A4SCN5ANR1I2PRKCA | |
| SCHEMBL4157359 | 0.94 | MTNR1A (0.35) | PRKCAMMP12MTNR1AMTNR1B | |
| SCHEMBL4157361 | 0.94 | MTNR1A (0.35) | PRKCAMMP12MTNR1AMTNR1B | |
| SCHEMBL4152682 | 0.93 | PRKCA (0.39) | KCNH2CYP3A4SCN5ANR1I2PRKCA | |
| SCHEMBL4149639 | 0.93 | PRKCA (0.39) | KCNH2CYP3A4SCN5ANR1I2PRKCA | |
| SCHEMBL4162139 | 0.91 | PRKCA (0.35) | KCNH2NR1I2PRKCAMMP12 | |
| SCHEMBL4162144 | 0.91 | PRKCA (0.35) | KCNH2NR1I2PRKCAMMP12 | |
| SCHEMBL4149821 | 0.91 | GHSR (0.38) | PRKCAMMP12 | |
| SCHEMBL4149818 | 0.91 | GHSR (0.38) | PRKCAMMP12 | |
| SCHEMBL4153077 | 0.90 | ESR1 (0.35) | KCNH2CYP3A4SCN5ANR1I2ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090136449-A1 | Tetracyclic Indole Derivatives as Antiviral Agents | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2009-05-28 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090136449-A1 | Tetracyclic Indole Derivatives as Antiviral Agents | IDO1, IDO2, ZC3HAV1 | KCNH2 1467/4885CYP3A4 68/4885SCN5A 3016/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.