Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.35 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4153074 | 1.00 | ESR1 (0.35) | ESR1KDM2BMTNR1AMTNR1BNR1I2 | |
| SCHEMBL4139156 | 0.95 | CNR2 (0.39) | CYP3A4ALDH1A1CNR1CNR2 | |
| SCHEMBL4139150 | 0.95 | CNR2 (0.39) | CYP3A4ALDH1A1CNR1CNR2 | |
| SCHEMBL4157358 | 0.92 | ALDH1A1 (0.38) | MTNR1AMTNR1BALDH1A1LMNAMAPT | |
| SCHEMBL4157356 | 0.92 | ALDH1A1 (0.38) | MTNR1AMTNR1BALDH1A1LMNAMAPT | |
| SCHEMBL4152682 | 0.92 | PRKCA (0.39) | ESR1MTNR1AMTNR1BNR1I2KCNH2 | |
| SCHEMBL4149639 | 0.92 | PRKCA (0.39) | ESR1MTNR1AMTNR1BNR1I2KCNH2 | |
| SCHEMBL4152580 | 0.91 | ALDH1A1 (0.37) | KCNH2CYP3A4ALDH1A1LMNAPOLB | |
| SCHEMBL4152577 | 0.91 | ALDH1A1 (0.37) | KCNH2CYP3A4ALDH1A1LMNAPOLB | |
| SCHEMBL4145150 | 0.90 | KCNH2 (0.35) | ESR1MTNR1AMTNR1BNR1I2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090136449-A1 | Tetracyclic Indole Derivatives as Antiviral Agents | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2009-05-28 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090136449-A1 | Tetracyclic Indole Derivatives as Antiviral Agents | IDO1, IDO2, ZC3HAV1 | ESR1 2872/4885KDM2B 3436/4885MTNR1A 45/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.