Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 2/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 8/20 | 0.36 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.35 |
| ▸ | CCR4 | P51679 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 5/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4139723 | 0.88 | MCHR1 (0.37) | PDK1PDK2PDK3PDK4HTR2A | |
| SCHEMBL4128118 | 0.88 | PDK1 (0.42) | PDK1PDK2PDK3PDK4HTR2A | |
| SCHEMBL4142298 | 0.87 | HRH3 (0.39) | HTR2AHTR2COPRL1KCNH2HRH3 | |
| SCHEMBL4140663 | 0.85 | HTR2C (0.42) | PDK1PDK2PDK3PDK4HTR2A | |
| SCHEMBL4145536 | 0.84 | CYP1A2 (0.36) | PDK1PDK2PDK3PDK4KCNH2 | |
| SCHEMBL4141821 | 0.84 | ALDH1A1 (0.39) | KCNH2HRH3 | |
| SCHEMBL4133152 | 0.84 | ASIC3 (0.40) | OPRL1KCNH2HRH3OPRM1OPRD1 | |
| SCHEMBL4135842 | 0.83 | CNR2 (0.43) | PDK1PDK2PDK3PDK4CNR1 | |
| SCHEMBL4141241 | 0.83 | PGR (0.39) | HTR2AHTR2CCHRNB1CHRNB2CHRNB4 | |
| SCHEMBL4136104 | 0.83 | MCHR1 (0.36) | PDK1PDK2PDK3PDK4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090163482-A1 | TETRALINES ANTAGONISTS OF THE H-3 RECEPTOR | MCHARDY STANTON FURST | 2009-06-25 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163482-A1 | TETRALINES ANTAGONISTS OF THE H-3 RECEPTOR | HRH3, HRH4, HRH1 | PDK1 3820/4885PDK2 2935/4885PDK3 2366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.