Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.50 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.50 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.50 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.50 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.50 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.94 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.94 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.70 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.59 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.52 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.52 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.52 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL414531 | 1.00 | TSHR (0.94) | TSHRALDH1A1TAAR1AOC3HRH3 | |
| Bromide SCHEMBL534887 | 1.00 | TSHR (0.94) | TSHRALDH1A1TAAR1AOC3HRH3 | |
| Benzene SCHEMBL27653708 | 1.00 | TSHR (0.94) | TSHRALDH1A1TAAR1AOC3HRH3 | |
| SCHEMBL15900 | 0.97 | TSHR (1.00) | TSHRALDH1A1TAAR1AOC3HRH3 | |
| SCHEMBL27766437 | 0.97 | TSHR (1.00) | TSHRALDH1A1TAAR1AOC3HRH3 | |
| SCHEMBL24735547 | 0.97 | TSHR (1.00) | TSHRALDH1A1TAAR1AOC3HRH3 | |
| SCHEMBL5014268 | 0.97 | TSHR (1.00) | TSHRALDH1A1TAAR1AOC3HRH3 | |
| Ammonia Solution, Strong SCHEMBL4071832 | 0.94 | TSHR (0.94) | TSHRALDH1A1TAAR1AOC3HRH3 | |
| Iodide SCHEMBL6672021 | 0.94 | TSHR (0.94) | TSHRALDH1A1TAAR1AOC3HRH3 | |
| Hydrochloric Acid SCHEMBL6391891 | 0.94 | TSHR (0.94) | TSHRALDH1A1TAAR1AOC3HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117567258-B | Preparation method of 2-bromo-1- (6-methoxynaphthalene-2-yl) acetone-1-ketone | 江苏八巨药业有限公司 | 2026-05-15 | — | — | CN | claimed |
| CN-117567258-A | Preparation method of 2-bromo-1- (6-methoxynaphthalene-2-yl) acetone-1-ketone | 江苏八巨药业有限公司 | 2024-02-20 | — | — | CN | claimed |
| CN-110563723-A | Preparation method of 6-bromo-3- (piperidine-4-yl) imidazo [1,2-a ] pyridine | 上海药明康德新药开发有限公司 | 2019-12-13 | — | — | CN | claimed |
| CN-117567258-B | Preparation method of 2-bromo-1- (6-methoxynaphthalene-2-yl) acetone-1-ketone | 江苏八巨药业有限公司 | 2026-05-15 | — | — | CN | disclosed |
| CN-117567258-B | Preparation method of 2-bromo-1- (6-methoxynaphthalene-2-yl) acetone-1-ketone | 江苏八巨药业有限公司 | 2026-05-15 | — | — | CN | disclosed |
| CN-117567258-A | Preparation method of 2-bromo-1- (6-methoxynaphthalene-2-yl) acetone-1-ketone | 江苏八巨药业有限公司 | 2024-02-20 | — | — | CN | disclosed |
| CN-114163294-B | Preparation method of 2-bromo-5-fluorobenzotrifluoride | 阜新宇泽化工有限公司 | 2023-12-26 | — | — | CN | disclosed |
| CN-116410419-A | Preparation method of anionic brominated branched butyl rubber | 中国石油天然气股份有限公司 | 2023-07-11 | — | — | CN | disclosed |
| CN-114163294-A | Preparation method of 2-bromo-5-fluorobenzotrifluoride | 阜新宇泽化工有限公司 | 2022-03-11 | — | — | CN | disclosed |
| CN-110563723-A | Preparation method of 6-bromo-3- (piperidine-4-yl) imidazo [1,2-a ] pyridine | 上海药明康德新药开发有限公司 | 2019-12-13 | — | — | CN | disclosed |
| CN-110563723-A | Preparation method of 6-bromo-3- (piperidine-4-yl) imidazo [1,2-a ] pyridine | 上海药明康德新药开发有限公司 | 2019-12-13 | — | — | CN | disclosed |
| US-20120022059-A1 | SUBSTITUTED FURANCARBOXAMIDES, AND USE THEREOF | AICURIS GMBH & CO. KG (DE) | 2012-01-26 | — | — | US | disclosed |
| EP-2376482-A1 | SUBSTITUTED (THIOPHENYL-CARBONYL)IMIDAZOLIDINONES, AND USE THEREOF | AiCuris GmbH & Co. KG (DE) | 2011-10-19 | — | — | EP | disclosed |
| US-8030347-B2 | Cylopenta[b]benzofuran derivatives and the utilization thereof | BAYER HEALTHCARE AG (DE) | 2011-10-04 | — | — | US | disclosed |
| WO-2011020822-A1 | SUBSTITUTED (THIAZOLYL-CARBONYL)IMIDAZOLIDINONES AND USE THEREOF FOR TREATING RETROVIRAL DISEASES | AICURIS GMBH & CO. KG (DE) | 2011-02-24 | — | — | WO | disclosed |
| WO-2010075962-A1 | SUBSTITUTED (THIOPHENYL-CARBONYL)IMIDAZOLIDINONES, AND USE THEREOF | AICURIS GMBH & CO. KG (DE) | 2010-07-08 | — | — | WO | disclosed |
| CN-101511796-A | Imidazole derivative | KYOWA HAKKO KOGYO KK (JP) | 2009-08-19 | — | — | CN | disclosed |
| US-20090018113-A1 | Novel Cylopenta[B]Benzofuran Derivatives and the Utilization Thereof | BAYER HEALTHCARE AG (DE) | 2009-01-15 | — | — | US | disclosed |
| EP-1751127-A2 | NOVEL CYLOPENTA¬B|BENZOFURAN DERIVATIVES AND THE UTILIZATION THEREOF | Bayer HealthCare AG (DE) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005113529-A2 | NOVEL CYLOPENTA[B]BENZOFURAN DERIVATIVES AND THE UTILIZATION THEREOF | BAYER HEALTHCARE AG (DE) | 2005-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022059-A1 | SUBSTITUTED FURANCARBOXAMIDES, AND USE THEREOF | AADAC, DDC, TPMT | ADRA2B 3694/4885ADRA2C 2794/4885SLC6A2 3317/4885 |
| US-20090018113-A1 | Novel Cylopenta[B]Benzofuran Derivatives and the Utilization Thereof | FKBP1A, FKBP2, FKBP1B | ADRA2B 2784/4885ADRA2C 3961/4885SLC6A2 4783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.