Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 18/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.44 |
| ▸ | KDR | P35968 | 3/20 | 0.44 |
| ▸ | TGFBR2 | P37173 | 3/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.44 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.44 |
| ▸ | TGFB2 | P61812 | 1/20 | 0.44 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.44 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.44 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.44 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL413710 | 0.95 | TGFBR1 (0.49) | TGFBR1MAPK14KDRTGFBR2GAK | |
| SCHEMBL412491 | 0.92 | TGFBR1 (0.57) | TGFBR1MAPK14KDRTGFBR2GAK | |
| SCHEMBL412319 | 0.92 | TGFBR1 (0.61) | TGFBR1MAPK14KDRTGFBR2GAK | |
| SCHEMBL413597 | 0.90 | TGFBR1 (0.48) | TGFBR1MAPK14KDRTGFBR2GAK | |
| SCHEMBL412989 | 0.89 | TGFBR1 (0.47) | TGFBR1MAPK14KDRTGFBR2GAK | |
| SCHEMBL414592 | 0.89 | TGFBR1 (0.47) | TGFBR1MAPK14KDRTGFBR2GAK | |
| SCHEMBL414211 | 0.88 | TGFBR1 (0.53) | TGFBR1MAPK14KDRTGFBR2GAK | |
| SCHEMBL409430 | 0.88 | TGFBR1 (0.49) | TGFBR1MAPK14KDRTGFBR2GAK | |
| SCHEMBL412977 | 0.88 | TGFBR1 (0.51) | TGFBR1MAPK14KDRTGFBR2GAK | |
| SCHEMBL412295 | 0.88 | NAMPT (0.50) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120021519-A1 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2012-01-26 | — | — | US | disclosed |