Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 9/20 | 0.43 |
| ▸ | PPARG | P37231 | 7/20 | 0.43 |
| ▸ | PPARA | Q07869 | 6/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 7/20 | 0.42 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7026 | 0.86 | AOC3 (0.37) | FFAR4 | |
| SCHEMBL6613 | 0.81 | FFAR4 (0.35) | FFAR4 | |
| SCHEMBL14854 | 0.81 | PPARD (0.42) | PPARDPPARGPPARAFFAR1SMPD1 | |
| SCHEMBL6082 | 0.79 | HDAC1 (0.34) | PPARDPPARGPPARAFFAR4 | |
| SCHEMBL7148 | 0.78 | ALDH1A1 (0.38) | FFAR1FFAR4 | |
| SCHEMBL6973 | 0.77 | BRD4 (0.36) | — | |
| SCHEMBL7534 | 0.75 | L3MBTL1 (0.34) | — | |
| SCHEMBL7666 | 0.74 | ABCC3 (0.44) | — | |
| SCHEMBL7297 | 0.73 | SCD5 (0.35) | — | |
| SCHEMBL6916 | 0.73 | BRD4 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483251-A2 | POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041462-A2 | POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |