Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7026 | 0.95 | AOC3 (0.37) | FFAR4SLC6A9ALOX5POLBMEN1 | |
| SCHEMBL7532 | 0.91 | ALOX5 (0.35) | SLC6A9ALOX5POLBMEN1KMT2A | |
| SCHEMBL7148 | 0.90 | ALDH1A1 (0.38) | FFAR4ALOX5MEN1KMT2ALPAR1 | |
| SCHEMBL1127 | 0.88 | LPAR1 (0.43) | FFAR4SLC6A9ALOX5POLBMEN1 | |
| SCHEMBL6973 | 0.86 | BRD4 (0.36) | SLC6A9ALOX5POLBMEN1KMT2A | |
| SCHEMBL1800 | 0.85 | CHRM1 (0.41) | SLC6A9ALOX5POLBMEN1KMT2A | |
| SCHEMBL7534 | 0.84 | L3MBTL1 (0.34) | LPAR1HSD11B1 | |
| SCHEMBL7297 | 0.83 | SCD5 (0.35) | ALOX5KMT2ALPAR1LMNACHRM5 | |
| SCHEMBL6150 | 0.83 | BRD4 (0.36) | FFAR4AOC3HSD11B1 | |
| SCHEMBL7666 | 0.82 | ABCC3 (0.44) | SLC6A9ALOX5POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |