Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | PLAAT3 | P53816 | 2/20 | 0.36 |
| ▸ | PLAAT5 | Q96KN8 | 2/20 | 0.36 |
| ▸ | PLAAT2 | Q9NWW9 | 2/20 | 0.36 |
| ▸ | PLAAT4 | Q9UL19 | 2/20 | 0.36 |
| ▸ | SNCA | P37840 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4148046 | 1.00 | ALDH1A1 (0.40) | ALDH1A1MEN1HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL4142774 | 0.80 | CNR1 (0.44) | ALDH1A1MEN1HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL4142778 | 0.80 | CNR1 (0.44) | ALDH1A1MEN1HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL4142769 | 0.80 | CNR1 (0.44) | ALDH1A1MEN1HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL14535996 | 0.77 | CNR1 (0.42) | OPRM1OPRD1OPRK1RAB9ANPC1 | |
| SCHEMBL4152846 | 0.72 | RAB9A (0.45) | ALDH1A1MEN1KMT2AOPRM1OPRD1 | |
| SCHEMBL4152840 | 0.72 | RAB9A (0.45) | ALDH1A1MEN1KMT2AOPRM1OPRD1 | |
| SCHEMBL4156820 | 0.68 | TAAR1 (0.47) | ALDH1A1MEN1HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL4135180 | 0.68 | TAAR1 (0.49) | MEN1KMT2AOPRM1OPRD1OPRK1 | |
| SCHEMBL4135175 | 0.68 | TAAR1 (0.49) | MEN1KMT2AOPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137557-A1 | Calcilytic Compounds | SMITHKLINE BEECHAM CORPORATION | 2009-05-28 | — | — | US | disclosed |
| US-20090137557-A1 | Calcilytic Compounds | SMITHKLINE BEECHAM CORPORATION | 2009-05-28 | — | — | US | disclosed |
| US-20090137557-A1 | Calcilytic Compounds | SMITHKLINE BEECHAM CORPORATION | 2009-05-28 | — | — | US | disclosed |
| CN-101360498-A | Calcilytic compounds | SMITHKLINE BEECHAM CORP (US) | 2009-02-04 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137557-A1 | Calcilytic Compounds | CALCR, SOST, CALCB | ALDH1A1 4674/4885MEN1 145/4885HPGD 2097/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.