Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 8/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | RAB9A | P51151 | 7/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.48 |
| ▸ | PKM | P14618 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
| ▸ | GFER | P55789 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3054720 | 0.84 | NPC1 (0.68) | NPBWR1NPC1ALDH1A1RAB9AKDM4E | |
| SCHEMBL15231864 | 0.80 | NPBWR1 (0.84) | NPBWR1 | |
| SCHEMBL9862039 | 0.80 | ALDH1A1 (0.69) | NPBWR1NPC1ALDH1A1RAB9AKDM4E | |
| SCHEMBL16497715 | 0.75 | ALDH1A1 (0.48) | NPC1ALDH1A1RAB9AKDM4EPKM | |
| SCHEMBL416600 | 0.74 | ALDH1A1 (0.74) | NPC1ALDH1A1RAB9AKDM4EPKM | |
| SCHEMBL417825 | 0.74 | ALDH1A1 (0.71) | NPC1ALDH1A1RAB9AKDM4EPKM | |
| SCHEMBL419961 | 0.74 | MEN1 (0.77) | NPBWR1NPC1ALDH1A1RAB9AKDM4E | |
| SCHEMBL57009 | 0.74 | POLB (0.57) | NPC1ALDH1A1RAB9AKDM4EPKM | |
| SCHEMBL30533210 | 0.74 | MEN1 (0.73) | NPBWR1NPC1ALDH1A1RAB9AKDM4E | |
| SCHEMBL1655753 | 0.74 | MEN1 (0.73) | NPBWR1NPC1ALDH1A1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8975416-B2 | Antibacterial compounds | SUMMIT CORPORATION PLC (GB) | 2015-03-10 | — | — | US | claimed |
| EP-2373631-B1 | ANTIBACTERIAL COMPOUNDS | SUMMIT CORP PLC (GB) | 2015-02-25 | — | — | EP | claimed |
| US-20120020950-A1 | ANTIBACTERIAL COMPOUNDS | SUMMIT CORPORATION PLC | 2012-01-26 | — | — | US | claimed |
| US-9763925-B2 | Antibacterial compounds | SUMMIT THERAPEUTICS PLC (GB) | 2017-09-19 | — | — | US | disclosed |
| EP-3095783-A1 | ANTIBACTERIAL COMPOUNDS | Summit Corporation Plc (GB) | 2016-11-23 | — | — | EP | disclosed |
| US-20160184283-A1 | ANTIBACTERIAL COMPOUNDS | SUMMIT (OXFORD) LIMITED (GB) | 2016-06-30 | — | — | US | disclosed |
| US-9314456-B2 | Antibacterial compounds | SUMMIT THERAPEUTICS PLC (GB) | 2016-04-19 | — | — | US | disclosed |
| EP-2907813-A1 | Antibacterial Compound | Summit Corporation Plc (GB) | 2015-08-19 | — | — | EP | disclosed |
| US-20150150861-A1 | ANTIBACTERIAL COMPOUNDS | SUMMIT (OXFORD) LIMITED (GB) | 2015-06-04 | — | — | US | disclosed |
| US-8975416-B2 | Antibacterial compounds | SUMMIT CORPORATION PLC (GB) | 2015-03-10 | — | — | US | disclosed |
| EP-2373631-B1 | ANTIBACTERIAL COMPOUNDS | SUMMIT CORP PLC (GB) | 2015-02-25 | — | — | EP | disclosed |
| US-20120020950-A1 | ANTIBACTERIAL COMPOUNDS | SUMMIT CORPORATION PLC | 2012-01-26 | — | — | US | disclosed |
| WO-2010063996-A2 | ANTIBACTERIAL COMPOUNDS | SUMMIT CORPORATION PLC (GB) | 2010-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160184283-A1 | ANTIBACTERIAL COMPOUNDS | MRPL21, RPN2, ALPI | NPBWR1 3876/4885NPC1 512/4885ALDH1A1 1088/4885 |
| US-20120020950-A1 | ANTIBACTERIAL COMPOUNDS | RPN2, MRPL21, ALPI | NPBWR1 3851/4885NPC1 509/4885ALDH1A1 1135/4885 |
| US-20150150861-A1 | ANTIBACTERIAL COMPOUNDS | MRPL21, RPN2, ALPI | NPBWR1 3876/4885NPC1 512/4885ALDH1A1 1088/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.