Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 7/20 | 0.57 |
| ▸ | EGFR | P00533 | 7/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.57 |
| ▸ | LTK | P29376 | 2/20 | 0.57 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.57 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.57 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.57 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.57 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.57 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.57 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.57 |
| ▸ | ABL1 | P00519 | 1/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.57 |
| ▸ | PIM1 | P11309 | 1/20 | 0.57 |
| ▸ | PRKACA | P17612 | 1/20 | 0.57 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.57 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethoxycarbonyl Group SCHEMBL27863143 | 0.85 | SMN1; SMN2 (0.48) | ABCG2EGFRMAP4K4LTKMAPK8 | |
| SCHEMBL29058817 | 0.80 | FLT1 (0.45) | EGFRERBB2KDRHTTMAPK1 | |
| SCHEMBL30395595 | 0.80 | FLT1 (0.45) | EGFRERBB2KDRHTTMAPK1 | |
| SCHEMBL8976752 | 0.79 | EGFR (0.78) | ABCG2EGFRMAP4K4LTKMAPK8 | |
| SCHEMBL27863154 | 0.77 | AURKA (0.34) | ABCG2EGFRMAP4K4LTKMAPK8 | |
| SCHEMBL8704247 | 0.77 | EGFR (0.63) | ABCG2EGFRKDR | |
| SCHEMBL31471762 | 0.76 | APP (0.52) | ABCG2AURKBRAB9AHTTNPC1 | |
| Hydrochloric Acid SCHEMBL7248432 | 0.76 | EGFR (0.64) | ABCG2EGFRKDRPDGFRA | |
| SCHEMBL6831353 | 0.76 | EGFR (0.62) | ABCG2EGFRMAP4K4LTKMAPK8 | |
| SCHEMBL29997075 | 0.75 | AURKA (0.62) | EGFRAURKBFGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090036474-A1 | Quinazoline derivatives for use against cancer | PLE PATRICK | 2009-02-05 | — | — | US | disclosed |
| US-20090036485-A1 | Quinoline derivatives | JUNG FREDERIC HENRI | 2009-02-05 | — | — | US | disclosed |
| EP-1802608-A1 | QUINAZOLINE DERIVATIVES FOR USE AGAINST CANCER | AstraZeneca AB (SE) | 2007-07-04 | — | — | EP | disclosed |
| EP-1802603-A1 | QUINOLINE DERIVATIVES | AstraZeneca AB (SE) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006040522-A1 | QUINOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2006-04-20 | — | — | WO | disclosed |
| WO-2006040526-A1 | QUINAZOLINE DERIVATIVES FOR USE AGAINST CANCER | ASTRAZENECA AB (SE) | 2006-04-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036485-A1 | Quinoline derivatives | AQP3, PGF, AQP1 | ABCG2 32/4885EGFR 1668/4885MAP4K4 1862/4885 |
| US-20090036474-A1 | Quinazoline derivatives for use against cancer | AQP3, AQP1, F12 | ABCG2 8/4885EGFR 713/4885MAP4K4 943/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.