Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 4/20 | 0.65 |
| ▸ | GABRD | O14764 | 4/20 | 0.65 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.65 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.65 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.65 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.65 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.65 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.65 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.65 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.65 |
| ▸ | GABRA4 | P48169 | 4/20 | 0.65 |
| ▸ | GABRE | P78334 | 4/20 | 0.65 |
| ▸ | GABRA6 | Q16445 | 4/20 | 0.65 |
| ▸ | GABRG1 | Q8N1C3 | 4/20 | 0.65 |
| ▸ | GABRG3 | Q99928 | 4/20 | 0.65 |
| ▸ | GABRQ | Q9UN88 | 4/20 | 0.65 |
| ▸ | MAOB | P27338 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4139637 | 0.88 | GABRP (0.69) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL23320376 | 0.85 | NPC1 (0.59) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL10172975 | 0.82 | GABRP (0.69) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL14900899 | 0.81 | TNKS (0.59) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7823812 | 0.78 | MAOB (0.63) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL9131248 | 0.77 | TNKS (0.67) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL10777972 | 0.76 | L3MBTL1 (0.56) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL18838092 | 0.76 | MAOB (0.57) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL4153246 | 0.74 | RAB9A (0.75) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL4990126 | 0.73 | GABRP (1.00) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090136448-A1 | Antiviral 2-Carboxy-Thiophene Compounds | CORFIELD JOHN ANDREW | 2009-05-28 | — | — | US | disclosed |
| US-20090136448-A1 | Antiviral 2-Carboxy-Thiophene Compounds | CORFIELD JOHN ANDREW | 2009-05-28 | — | — | US | disclosed |
| US-20090136448-A1 | Antiviral 2-Carboxy-Thiophene Compounds | CORFIELD JOHN ANDREW | 2009-05-28 | — | — | US | disclosed |
| EP-1971599-A1 | ANTIVIRAL 2-CARBOXY-THIOPHENE COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-09-24 | — | — | EP | disclosed |
| WO-2007071434-A1 | ANTIVIRAL 2-CARBOXY-THIOPHENE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-06-28 | — | — | WO | disclosed |
| WO-2007071434-A1 | ANTIVIRAL 2-CARBOXY-THIOPHENE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-06-28 | — | — | WO | disclosed |
| WO-2007039146-A1 | 4-CARBOXY PYRAZOLE DERIVATIVES AS ANTI-VIRAL AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090136448-A1 | Antiviral 2-Carboxy-Thiophene Compounds | EIF2AK2, HAVCR2, MAVS | GABRP 2812/4885GABRD 4396/4885GABRA1 3914/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.