Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14208559 | 0.90 | MAPK10 (0.50) | MAPK8MAPK9MAPK10KMT2APKM | |
| SCHEMBL4149920 | 0.83 | NPC1 (0.45) | MAPK8MAPK9MAPK10L3MBTL1KMT2A | |
| SCHEMBL2493883 | 0.79 | KMT2A (0.51) | L3MBTL1KMT2APKMALDH1A1SMN1; SMN2 | |
| SCHEMBL1522388 | 0.77 | ALDH1A1 (0.43) | MAPK8MAPK9MAPK10L3MBTL1KMT2A | |
| SCHEMBL1522389 | 0.77 | ALDH1A1 (0.43) | MAPK8MAPK9MAPK10L3MBTL1KMT2A | |
| SCHEMBL1523622 | 0.76 | KMT2A (0.45) | L3MBTL1KMT2AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL3851346 | 0.73 | ALDH1A1 (0.49) | L3MBTL1KMT2AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL11476699 | 0.71 | ALDH1A1 (0.47) | L3MBTL1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL17181731 | 0.71 | KMT2A (0.43) | L3MBTL1KMT2APKMALDH1A1SMN1; SMN2 | |
| SCHEMBL11190772 | 0.71 | RAB9A (0.72) | L3MBTL1KMT2AALDH1A1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090176825-A1 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION | 2009-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090176825-A1 | PROLYL HYDROXYLASE INHIBITORS | HIF1AN, EGLN2, EGLN3 | MAPK8 4026/4885MAPK9 3876/4885MAPK10 4072/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.