Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | PPID | Q08752 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4150824 | 0.83 | MAPK8 (0.49) | NPC1RAB9AL3MBTL1MAPK8MAPK9 | |
| SCHEMBL14208559 | 0.73 | MAPK10 (0.50) | RAB9AMAPK8MAPK9MAPK10ALDH1A1 | |
| SCHEMBL1523622 | 0.72 | KMT2A (0.45) | NPC1RAB9AL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL11190772 | 0.70 | RAB9A (0.72) | NPC1RAB9AL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3851346 | 0.69 | ALDH1A1 (0.49) | NPC1RAB9AL3MBTL1ALDH1A1SMN1; SMN2 | |
| Malonic Acid Diethyl Ester SCHEMBL11067701 | 0.69 | ALDH1A1 (0.57) | NPC1RAB9AL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4154527 | 0.69 | KMT2A (0.57) | NPC1RAB9AL3MBTL1MAPK10ALDH1A1 | |
| SCHEMBL3508863 | 0.68 | MAPK8 (0.50) | NPC1RAB9AMAPK8MAPK10ALDH1A1 | |
| SCHEMBL9686760 | 0.68 | PIN1 (0.53) | NPC1RAB9AL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5461474 | 0.68 | NPC1 (0.61) | NPC1RAB9AALDH1A1SMN1; SMN2LTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090176825-A1 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION | 2009-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090176825-A1 | PROLYL HYDROXYLASE INHIBITORS | HIF1AN, EGLN2, EGLN3 | NPC1 1595/4885RAB9A 4158/4885L3MBTL1 1964/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.