SCHEMBL4151156

SCHEMBL4151156

Cc1cc(Cl)cc(C(=O)NC(C)C2CC2)c1NC(=O)c1cc(Br)nn1-c1ccccc1Cl

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RIPK1 Q13546 1/20 0.39
IDO1 P14902 3/20 0.37
CCR8 P51685 1/20 0.37
CNR1 P21554 2/20 0.37
CNR2 P34972 2/20 0.37
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
F10 P00742 1/20 0.35
TAS1R3 Q7RTX0 1/20 0.35
TAS1R1 Q7RTX1 1/20 0.35
MAPK14 Q16539 1/20 0.34
KDM4E B2RXH2 2/20 0.33
ALDH1A1 P00352 2/20 0.33
DRD4 P21917 1/20 0.33
HPGD P15428 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
RXFP1 Q9HBX9 1/20 0.33
ATM Q13315 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
MET P08581 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29416550 0.88 DHODH (0.40) RIPK1IDO1CNR1CNR2NPC1
SCHEMBL195314 0.88 DHODH (0.40) RIPK1IDO1CNR1CNR2NPC1
SCHEMBL4149532 0.84 CHRM1 (0.40) CNR1CNR2NPC1RAB9AMAPK14
SCHEMBL29416624 0.81 IDO1 (0.38) RIPK1IDO1CNR1CNR2NPC1
SCHEMBL196132 0.81 IDO1 (0.38) RIPK1IDO1CNR1CNR2NPC1
SCHEMBL29416636 0.80 IDO1 (0.38) RIPK1IDO1CNR1CNR2NPC1
SCHEMBL27174182 0.80 IDO1 (0.38) RIPK1IDO1CNR1CNR2NPC1
SCHEMBL230723 0.80 IDO1 (0.38) RIPK1IDO1CNR1CNR2NPC1
SCHEMBL29355401 0.80 IDO1 (0.38) RIPK1IDO1CNR1CNR2NPC1
SCHEMBL1385164 0.80 PYGL (0.38) RIPK1CNR1CNR2MAPK14ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090133318-A1 Anthranilamide insecticides E. I. DU PONT DE NEMOURS AND COMPANY 2009-05-28 US claimed
EP-2564706-A1 Anthranilamide insecticides E. I. du Pont de Nemours and Company (US) 2013-03-06 EP disclosed
US-20090133318-A1 Anthranilamide insecticides E. I. DU PONT DE NEMOURS AND COMPANY 2009-05-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090133318-A1 Anthranilamide insecticides C3AR1, C5, C1S RIPK1 3487/4885IDO1 143/4885CCR8 167/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.