SCHEMBL4149532

SCHEMBL4149532

Cc1cc(Cl)cc(C(=O)NCC2CC2)c1NC(=O)c1cc(Br)nn1-c1ccccc1Cl

nearest known ligand 0.57

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CHRM1 P11229 6/20 0.40
CHRM2 P08172 1/20 0.40
CHRM4 P08173 1/20 0.40
CHRM5 P08912 1/20 0.40
CHRM3 P20309 1/20 0.40
CNR2 P34972 4/20 0.39
CNR1 P21554 3/20 0.39
LMNA P02545 1/20 0.38
TP53 P04637 1/20 0.38
MAPK14 Q16539 1/20 0.37
KCNH2 Q12809 1/20 0.37
CACNA1I Q9P0X4 1/20 0.37
NPC1 O15118 2/20 0.37
KDM4E B2RXH2 1/20 0.36
MAPT P10636 1/20 0.36
PKM P14618 1/20 0.36
RAB9A P51151 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4165682 0.90 CNR1 (0.38) CHRM1CHRM2CHRM4CHRM5CHRM3
SCHEMBL2138302 0.88 P2RX7 (0.41) CHRM1CHRM2CHRM4CHRM5CHRM3
SCHEMBL4151156 0.84 RIPK1 (0.39) CNR2CNR1TP53MAPK14NPC1
SCHEMBL12528992 0.80 TP53 (0.35) CNR2TP53MAPT
SCHEMBL121591 0.80 DHODH (0.40) CHRM4
SCHEMBL4155986 0.79 SMO (0.40) LMNAMAPTRAB9A
SCHEMBL320836 0.79 P2RX7 (0.42) CHRM1KCNH2CACNA1I
SCHEMBL2138881 0.79 P2RX7 (0.39) CHRM1CHRM2CHRM4CHRM5CHRM3
SCHEMBL12527673 0.78 POLB (0.35) CNR2TP53MAPT
SCHEMBL2138745 0.78 L3MBTL1 (0.36) CNR2TP53KDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090133318-A1 Anthranilamide insecticides E. I. DU PONT DE NEMOURS AND COMPANY 2009-05-28 US claimed
EP-1812421-A2 ANTHRANILAMIDE INSECTICIDES E.I. DUPONT DE NEMOURS AND COMPANY (US) 2007-08-01 EP claimed
WO-2006055922-A2 ANTHRANILAMIDE INSECTICIDES E.I. DUPONT DE NEMOURS AND COMPANY (US) 2006-05-26 WO claimed
EP-2564706-A1 Anthranilamide insecticides E. I. du Pont de Nemours and Company (US) 2013-03-06 EP disclosed
US-20090133318-A1 Anthranilamide insecticides E. I. DU PONT DE NEMOURS AND COMPANY 2009-05-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090133318-A1 Anthranilamide insecticides C3AR1, C5, C1S CHRM1 40/4885CHRM2 67/4885CHRM4 354/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.