Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MMP8 | P22894 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | KDM4A | O75164 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4149806 | 0.84 | POLB (0.64) | KMT2ACYP2D6CYP2C9CYP2C19POLB | |
| SCHEMBL4138386 | 0.81 | MMP8 (0.65) | KMT2ACYP2D6CYP2C9CYP2C19POLB | |
| SCHEMBL4145237 | 0.81 | POLB (0.57) | KMT2ACYP2D6CYP2C9CYP2C19POLB | |
| SCHEMBL4144621 | 0.78 | MMP3 (0.50) | KMT2ACYP2D6CYP2C9CYP2C19POLB | |
| SCHEMBL3385526 | 0.77 | KMT2A (0.59) | KMT2ACYP2D6CYP2C9CYP2C19POLB | |
| SCHEMBL10537039 | 0.76 | POLB (0.57) | KMT2ACYP2D6CYP2C9CYP2C19POLB | |
| SCHEMBL1027805 | 0.75 | SMN1; SMN2 (0.64) | KMT2ACYP2C19ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7866857 | 0.75 | KMT2A (0.81) | KMT2ACYP2D6CYP2C9CYP2C19POLB | |
| SCHEMBL4151569 | 0.75 | POLB (0.64) | KMT2ACYP2D6CYP2C9CYP2C19POLB | |
| Hydrochloric Acid SCHEMBL27729415 | 0.73 | KMT2A (0.78) | KMT2ACYP2D6CYP2C9CYP2C19POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137557-A1 | Calcilytic Compounds | SMITHKLINE BEECHAM CORPORATION | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137557-A1 | Calcilytic Compounds | CALCR, SOST, CALCB | KMT2A 4875/4885CYP2D6 1412/4885CYP2C9 1391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.