SCHEMBL4151653

SCHEMBL4151653

CCOC(=O)c1ccc(C(=NOC)c2ccc3c(c2)C(C)(C)CCN3CCOc2ccc(C[C@H](OCC)C(=O)OCC)cc2)cc1

nearest known ligand 0.89

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 16/20 0.89
PPARG P37231 15/20 0.89
RARA P10276 3/20 0.47
RARB P10826 3/20 0.47
RXRA P19793 1/20 0.39
RXRB P28702 1/20 0.39
RXRG P48443 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4151651 1.00 PPARA (0.89) PPARAPPARGRARARARBRXRA
SCHEMBL4156950 0.94 PPARG (1.00) PPARAPPARGRARARARBRXRA
SCHEMBL5320006 0.94 PPARG (0.92) PPARAPPARGRARARARBRXRA
SCHEMBL4156954 0.94 PPARG (1.00) PPARAPPARGRARARARBRXRA
SCHEMBL4152661 0.90 PPARG (0.72) PPARAPPARGRARARARB
SCHEMBL4152666 0.90 PPARG (0.72) PPARAPPARGRARARARB
SCHEMBL4144941 0.88 PPARG (0.92) PPARAPPARGRXRARXRBRXRG
SCHEMBL4144244 0.88 PPARG (1.00) PPARAPPARG
SCHEMBL4146973 0.88 PPARG (1.00) PPARAPPARG
SCHEMBL4146970 0.88 PPARG (1.00) PPARAPPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090124656-A1 Heterocyclic Oxime Compounds a Process for Their Preparation and Pharmaceutical Compositions Containing Them LES LABORATOIRES SERVIER (FR) 2009-05-14 US claimed
US-20090124656-A1 Heterocyclic Oxime Compounds a Process for Their Preparation and Pharmaceutical Compositions Containing Them LES LABORATOIRES SERVIER (FR) 2009-05-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090124656-A1 Heterocyclic Oxime Compounds a Process for Their Preparation and Pharmaceutical Compositions Containing Them GPR119, HBB, CYP3A7 PPARA 1020/4885PPARG 969/4885RARA 1550/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.