Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.34 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19004692 | 0.72 | HSPA1A (0.38) | HSPA1APTPN7TDP1MAPTGAA | |
| SCHEMBL454276 | 0.72 | HSPA1A (0.38) | HSPA1APTPN7TDP1MAPTGAA | |
| SCHEMBL15704498 | 0.72 | HSPA1A (0.38) | HSPA1APTPN7TDP1MAPTGAA | |
| Hydrochloric Acid SCHEMBL6829790 | 0.69 | PARP1 (0.32) | MAPTMEN1KMT2A | |
| SCHEMBL8080080 | 0.67 | MAPT (0.36) | HSPA1APTPN7TDP1MAPTGAA | |
| SCHEMBL10061181 | 0.66 | HSPA1A (0.34) | HSPA1APTPN7TDP1MAPTGAA | |
| Acetic Acid SCHEMBL11557554 | 0.63 | HSPA1A (0.44) | HSPA1APTPN7TDP1MAPTGAA | |
| SCHEMBL19041873 | 0.63 | HSPA1A (0.35) | HSPA1APTPN7TDP1MAPTGAA | |
| SCHEMBL22652982 | 0.63 | PIM1 (0.37) | HSPA1APTPN7TDP1MAPTGAA | |
| SCHEMBL22385927 | 0.62 | PIM1 (0.35) | HSPA1APTPN7TDP1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090247520-A1 | INHIBITORS OF ANTIGEN RECEPTOR-INDUCED NF-kappa B ACTIVATION | THE BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247520-A1 | INHIBITORS OF ANTIGEN RECEPTOR-INDUCED NF-kappa B ACTIVATION | NFKBIA, IKBKB, NFRKB | HSPA1A 993/4885PTPN7 567/4885TDP1 3894/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.