Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.35 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6312246 | 0.77 | CREBBP (0.34) | — | |
| SCHEMBL15704498 | 0.77 | HSPA1A (0.38) | MAPTKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL454276 | 0.77 | HSPA1A (0.38) | MAPTKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL19004692 | 0.77 | HSPA1A (0.38) | MAPTKDM4EMEN1ALDH1A1HPGD | |
| Acetic Acid SCHEMBL11557554 | 0.68 | HSPA1A (0.44) | MAPTALDH1A1KMT2AMCL1L3MBTL1 | |
| SCHEMBL10061181 | 0.67 | HSPA1A (0.34) | MAPTKDM4EMEN1ALDH1A1HPGD | |
| Iodide SCHEMBL4151879 | 0.67 | HSPA1A (0.34) | MAPTKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL13418916 | 0.67 | MAPT (0.38) | MAPTKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL13956198 | 0.66 | MAPT (0.40) | MAPTKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL13349415 | 0.66 | PBRM1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0251194-B1 | USE OF CARBOCYCLIC AND HETEROCYCLIC CONDENSED DIHYDROPYRIDINES FOR THE PREPARATION OF CARDIOPROTECTIVE REMEDIES AND HETEROCYCLIC AND CARBOCYCLIC CONDENSED DIHYDROPYRIDINES AND METHODS AND INTERMEDIATES FOR THEIR PREPARATION | BOEHRINGER INGELHEIM KG (DE) | 1993-03-31 | — | — | EP | claimed |
| EP-0251194-A1 | Use of carbocyclic and heterocyclic condensed dihydropyridines for the preparation of cardioprotective remedies and heterocyclic and carbocyclic condensed dihydropyridines and methods and intermediates for their preparation | BOEHRINGER INGELHEIM KG (DE) | 1988-01-07 | — | — | EP | claimed |
| US-6034094-A | BRAIN DISORDERS; ANTICOAGULANTS; ANTIINFLAMMATORY AGENTS | BOEHRINGER INGELHEIM KG (DE) | 2000-03-07 | — | — | US | disclosed |
| EP-0563128-B1 | NEW 3,4-DIHYDROISOQUINOLINE DERIVATES AND NEW PHARMACEUTICAL USE OF CARBOCYCLICALLY AND HETEROCYCLICALLY ANNULATED DIHYDROPYRIDINES | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-03-24 | — | — | EP | disclosed |
| US-5686462-A | FUSED DIHYDROPYRIDINES | BOEHRINGER INGELHEIM KG (DE) | 1997-11-11 | — | — | US | disclosed |
| US-5665729-A | CARBOCYCLIC OR HETEROCYCLIC FUSED DIHYDROPYRIDINES | BOEHRINGER INGELHEIM KG (DE) | 1997-09-09 | — | — | US | disclosed |
| EP-0781556-A1 | Use of condensed dihydropyridines for the treatement of chronic inflammatory processes | BOEHRINGER INGELHEIM KG (DE) | 1997-07-02 | — | — | EP | disclosed |
| EP-0251194-B1 | USE OF CARBOCYCLIC AND HETEROCYCLIC CONDENSED DIHYDROPYRIDINES FOR THE PREPARATION OF CARDIOPROTECTIVE REMEDIES AND HETEROCYCLIC AND CARBOCYCLIC CONDENSED DIHYDROPYRIDINES AND METHODS AND INTERMEDIATES FOR THEIR PREPARATION | BOEHRINGER INGELHEIM KG (DE) | 1993-03-31 | — | — | EP | disclosed |
| EP-0251194-A1 | Use of carbocyclic and heterocyclic condensed dihydropyridines for the preparation of cardioprotective remedies and heterocyclic and carbocyclic condensed dihydropyridines and methods and intermediates for their preparation | BOEHRINGER INGELHEIM KG (DE) | 1988-01-07 | — | — | EP | disclosed |