Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 7/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.32 |
| ▸ | ACHE | P22303 | 2/20 | 0.32 |
| ▸ | F11 | P03951 | 2/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4136765 | 0.88 | BDKRB1 (0.43) | BDKRB1HTR6SMYD3OPRD1ACHE | |
| SCHEMBL4149068 | 0.87 | BDKRB1 (0.46) | BDKRB1HTR6SMYD3OPRD1ACHE | |
| SCHEMBL4139938 | 0.84 | BDKRB1 (0.37) | BDKRB1OPRD1ACHEF11 | |
| SCHEMBL4142421 | 0.84 | BDKRB1 (0.44) | BDKRB1OPRD1ACHEF11 | |
| SCHEMBL4147340 | 0.82 | BDKRB1 (0.43) | BDKRB1SMYD3OPRD1ACHEF11 | |
| SCHEMBL4146216 | 0.77 | BDKRB1 (0.41) | BDKRB1OPRD1 | |
| SCHEMBL3532525 | 0.76 | BDKRB1 (0.42) | BDKRB1OPRD1 | |
| SCHEMBL3535804 | 0.76 | BDKRB1 (0.42) | BDKRB1OPRD1 | |
| SCHEMBL4136762 | 0.74 | ACHE (0.39) | BDKRB1OPRD1ACHEF11 | |
| SCHEMBL4148578 | 0.73 | SMYD3 (0.41) | SMYD3OPRD1ACHEF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090048224-A1 | COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2009-02-19 | — | — | US | disclosed |
| US-7425631-B2 | Compounds and methods of use | AMGEN INC. (US) | 2008-09-16 | — | — | US | disclosed |
| EP-1631542-A1 | BICYCLIC COMPOUNDS HAVING BRADYKININ RECEPTORS AFFINITY AND PHARMACEUTICAL COMPOSITIONS THEREOF | Amgen, Inc. (US) | 2006-03-08 | — | — | EP | disclosed |
| US-20050124654-A1 | Compounds and methods of use | AMGEN INC. | 2005-06-09 | — | — | US | disclosed |
| WO-2004092116-A1 | BICYCLIC COMPOUNDS HAVING BRADYKININ RECEPTORS AFFINITY AND PHARMACEUTICAL COMPOSITIONS THEREOF | AMGEN, INC. (US) | 2004-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124654-A1 | Compounds and methods of use | LTC4S, PTGES, LTB4R2 | BDKRB1 51/4885HTR6 1147/4885SMYD3 4240/4885 |
| US-20090048224-A1 | COMPOUNDS AND METHODS OF USE | LTC4S, PTGES, LTB4R2 | BDKRB1 51/4885HTR6 1147/4885SMYD3 4240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.