Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 7/20 | 0.51 |
| ▸ | MAOA | P21397 | 2/20 | 0.51 |
| ▸ | MAOB | P27338 | 2/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 2/20 | 0.46 |
| ▸ | F9 | P00740 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 5/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4143247 | 0.85 | NPC1 (0.52) | KDM1AMAOAMAOBHTR1ASLC6A2 | |
| Hydrochloric Acid SCHEMBL5743216 | 0.82 | F2 (0.52) | F10F9F2 | |
| SCHEMBL4153049 | 0.81 | NPC1 (0.55) | KDM1AMAOAMAOBHTR1ASLC6A2 | |
| SCHEMBL26942219 | 0.80 | KDM1A (0.61) | KDM1AMAOAMAOBHTR1ASLC6A2 | |
| SCHEMBL4145578 | 0.78 | ALDH1A1 (0.58) | KDM1AMAOAMAOBHTR1ASLC6A2 | |
| Hydrochloric Acid SCHEMBL28517934 | 0.77 | KDM1A (0.40) | KDM1AMAOAMAOBF10F2 | |
| SCHEMBL5313068 | 0.77 | NPC1 (0.50) | KDM1AMAOAMAOBHTR1ASLC6A2 | |
| Hydrochloric Acid SCHEMBL28326085 | 0.76 | MAOB (0.43) | MAOBF10F9F2 | |
| SCHEMBL9183339 | 0.76 | F10 (0.45) | KDM1ANPC1F10F9F2 | |
| SCHEMBL3407002 | 0.76 | KDM1A (0.57) | KDM1AMAOAMAOBHTR1ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137557-A1 | Calcilytic Compounds | SMITHKLINE BEECHAM CORPORATION | 2009-05-28 | — | — | US | disclosed |
| US-20090137557-A1 | Calcilytic Compounds | SMITHKLINE BEECHAM CORPORATION | 2009-05-28 | — | — | US | disclosed |
| US-20090137557-A1 | Calcilytic Compounds | SMITHKLINE BEECHAM CORPORATION | 2009-05-28 | — | — | US | disclosed |
| EP-1951244-A2 | CALCILYTIC COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007062370-A2 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137557-A1 | Calcilytic Compounds | CALCR, SOST, CALCB | KDM1A 4865/4885MAOA 3846/4885MAOB 2740/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.