Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IFNAR1 | P17181 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 11/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.41 |
| ▸ | HTR2A | P28223 | 6/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27650320 | 0.83 | BCHE (0.43) | PTGS2GAA | |
| SCHEMBL1254044 | 0.79 | IFNAR1 (0.49) | IFNAR1SLC6A4SLC6A2SLC6A3HTR2A | |
| SCHEMBL28948705 | 0.79 | PTGS2 (0.42) | PTGS2HTR2ACYP2A6L3MBTL1 | |
| SCHEMBL4153648 | 0.79 | IFNAR1 (0.45) | IFNAR1SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL9857923 | 0.76 | KDM4E (0.46) | IFNAR1SLC6A4SLC6A2SLC6A3PTGS2 | |
| SCHEMBL4161556 | 0.76 | CA1 (0.47) | IFNAR1SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL28611445 | 0.76 | L3MBTL1 (0.41) | PTGS2HTR2ACYP2A6L3MBTL1 | |
| SCHEMBL2769756 | 0.76 | MEN1 (0.40) | PTGS2 | |
| SCHEMBL2769421 | 0.76 | HTR2A (0.50) | PTGS2HTR2ACYP2A6L3MBTL1 | |
| SCHEMBL15352016 | 0.76 | L3MBTL1 (0.41) | PTGS2HTR2ACYP2A6L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100534983-C | Cyclic amine derivatives, processes for their preparation, and pharmaceutical compositions containing them | GLAXO GROUP LTD (GB) | 2009-09-02 | — | — | CN | disclosed |
| US-20090192194-A1 | Cyclic Amine Derivatives, Processes For Their Preparation, And Pharmaceutical Compositions Containing Them | ALVARO GIUSEPPE | 2009-07-30 | — | — | US | disclosed |
| US-20070073061-A1 | Cyclic amine derivatives, processes for their preparation, and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 2007-03-29 | — | — | US | disclosed |
| CN-1819995-A | Cyclic amine derivatives, processes for their preparation, and pharmaceutical compositions containing them | GLAXO GROUP LTD (GB) | 2006-08-16 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070073061-A1 | Cyclic amine derivatives, processes for their preparation, and pharmaceutical compositions containing them | SLC6A4, OPRL1, HCRTR1 | IFNAR1 977/4885SLC6A4 1/4885SLC6A2 33/4885 |
| US-20090192194-A1 | Cyclic Amine Derivatives, Processes For Their Preparation, And Pharmaceutical Compositions Containing Them | SLC6A4, OPRL1, HCRTR1 | IFNAR1 977/4885SLC6A4 1/4885SLC6A2 33/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.