Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.36 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MC5R | P33032 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27650320 | 0.79 | BCHE (0.43) | MEN1KMT2ASMN1; SMN2MAPK1MC5R | |
| SCHEMBL4153142 | 0.76 | IFNAR1 (0.45) | PTGS2 | |
| SCHEMBL2771330 | 0.74 | CASR (0.37) | SMN1; SMN2CYP2D6 | |
| SCHEMBL13430504 | 0.72 | KMT2A (0.49) | MEN1KMT2ASMPD1DNM1MAPK1 | |
| SCHEMBL31227163 | 0.71 | HTT (0.44) | CYP1A2CYP2D6ALDH1A1 | |
| SCHEMBL2769396 | 0.71 | POLB (0.38) | MEN1KMT2ASMN1; SMN2DNM1CYP1A2 | |
| SCHEMBL5200340 | 0.70 | TACR1 (0.34) | MEN1KMT2ACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL28948705 | 0.70 | PTGS2 (0.42) | CYP1A2CYP2D6CYP2C19PTGS2ALDH1A1 | |
| SCHEMBL13576841 | 0.70 | ACLY (0.47) | MEN1KMT2ASMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL19643755 | 0.70 | HTT (0.43) | MEN1KMT2ASMN1; SMN2CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753739-B1 | IMIDAZOL-2-ONE COMPOUNDS USEFUL IN THE TREATMENT OF VARIOUS DISORDERS | GLAXO GROUP LTD (GB) | 2010-04-28 | — | — | EP | disclosed |
| US-7534893-B2 | Imidazol-2-one compounds useful in the treatment of various disorders | GLAXO GROUP LIMITED (GB) | 2009-05-19 | — | — | US | disclosed |
| US-20070249679-A1 | Imidazol-2-One Compounds Useful in the Treatment of Various Disorders | GLAXO GROUP LIMITED (GB) | 2007-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249679-A1 | Imidazol-2-One Compounds Useful in the Treatment of Various Disorders | SLC6A4, SLC18A2, SLC18A1 | MEN1 1835/4885KMT2A 2977/4885SMN1; SMN2 1787/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.