Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | UBE2M | P61081 | 3/20 | 0.40 |
| ▸ | DCUN1D1 | Q96GG9 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4606072 | 0.87 | SIGMAR1 (0.52) | SIGMAR1 | |
| Trifluoroacetic Acid SCHEMBL4164045 | 0.85 | TSHR (0.44) | CYP2C19SMN1; SMN2TSHRSIGMAR1UBE2M | |
| Trifluoroacetic Acid SCHEMBL4159826 | 0.83 | CCR2 (0.49) | TSHRSIGMAR1UBE2MDCUN1D1KMT2A | |
| Trifluoroacetic Acid SCHEMBL4161039 | 0.81 | SIGMAR1 (0.57) | SIGMAR1DRD2DRD4 | |
| Trifluoroacetic Acid SCHEMBL4171437 | 0.81 | SIGMAR1 (0.47) | SMN1; SMN2SIGMAR1DRD4 | |
| Trifluoroacetic Acid SCHEMBL4150100 | 0.80 | CHRM2 (0.42) | TSHRSIGMAR1UBE2MDCUN1D1DRD2 | |
| Trifluoroacetic Acid SCHEMBL4156514 | 0.79 | SMN1; SMN2 (0.37) | SMN1; SMN2ACEKMT2A | |
| Trifluoroacetic Acid SCHEMBL4622701 | 0.79 | CHRM1 (0.46) | SIGMAR1UBE2MDCUN1D1 | |
| SCHEMBL5121666 | 0.79 | CYP2C19 (0.53) | CYP2C19SMN1; SMN2TSHRL3MBTL1SIGMAR1 | |
| Trifluoroacetic Acid SCHEMBL4154008 | 0.76 | CHRM2 (0.38) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054448-A1 | Amino Acid Derivatives as Histone Deacetylase (HDAC) Inhibitors | JONES PHILIP | 2009-02-26 | — | — | US | disclosed |
| EP-1945609-A2 | AMINO ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007029036-A2 | AMINO ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2007-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054448-A1 | Amino Acid Derivatives as Histone Deacetylase (HDAC) Inhibitors | HDAC5, HDAC1, HDAC11 | CYP2C19 2603/4885SMN1; SMN2 1280/4885TSHR 1377/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.