SCHEMBL4154477

SCHEMBL4154477

CN(C(=O)NC(=O)c1c(F)cccc1F)c1ccc(SC(F)(F)C(F)OC(F)(F)F)cc1F

nearest known ligand 0.33

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.33
USP2 O75604 1/20 0.33
MAPT P10636 1/20 0.33
ALOX15 P16050 1/20 0.33
KMT2A Q03164 1/20 0.33
ATM Q13315 1/20 0.32
TRPA1 O75762 2/20 0.32
RAB9A P51151 1/20 0.31
TLR7 Q9NYK1 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4145038 0.89 ATM (0.35) MEN1USP2MAPTALOX15KMT2A
SCHEMBL4158482 0.87 MEN1 (0.39) MEN1USP2MAPTALOX15KMT2A
SCHEMBL4158996 0.85 TRPA1 (0.34) MEN1MAPTKMT2AATMTRPA1
SCHEMBL4162989 0.83 RORC (0.32) TLR7
SCHEMBL4155015 0.83 TLR7 (0.40) MAPTRAB9ATLR7
SCHEMBL4151007 0.83 TRPA1 (0.33) MEN1USP2MAPTALOX15KMT2A
SCHEMBL4146966 0.81 ATM (0.34) MEN1USP2MAPTALOX15KMT2A
SCHEMBL4150885 0.81 MEN1 (0.39) MEN1USP2MAPTALOX15KMT2A
SCHEMBL13774542 0.81 TRPA1 (0.32) MEN1USP2MAPTALOX15KMT2A
SCHEMBL4163009 0.81 KMT2A (0.34) MEN1USP2MAPTALOX15KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090176786-A1 Benzoylurea Compounds and Use Thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-07-09 US disclosed
EP-1937629-A2 BENZOYLUREA COMPOUNDS AND USE THEREOF Sumitomo Chemical Company, Limited (JP) 2008-07-02 EP disclosed
WO-2007046513-A2 BENZOYLUREA COMPOUNDS AND USE THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-04-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090176786-A1 Benzoylurea Compounds and Use Thereof BTK, BRIX1, NFXL1 MEN1 1863/4885USP2 1667/4885MAPT 4585/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.