Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.60 |
| ▸ | SRC | P12931 | 6/20 | 0.60 |
| ▸ | ZAP70 | P43403 | 5/20 | 0.60 |
| ▸ | CDK2 | P24941 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4150544 | 0.86 | SYK (0.46) | SYKSRCZAP70CDK2 | |
| SCHEMBL4146823 | 0.83 | IKBKB (0.57) | CDK2 | |
| SCHEMBL4151825 | 0.82 | ABL1 (0.52) | SRCCDK2 | |
| SCHEMBL4138329 | 0.81 | ABL1 (0.60) | SRCZAP70 | |
| SCHEMBL4159422 | 0.79 | CDK2 (0.42) | SYKCDK2 | |
| SCHEMBL13924432 | 0.76 | SYK (1.00) | SYKSRCZAP70CDK2 | |
| SCHEMBL4156267 | 0.75 | SYK (0.65) | SYKSRCZAP70CDK2 | |
| SCHEMBL13924503 | 0.75 | SYK (0.78) | SYKSRCZAP70CDK2 | |
| SCHEMBL13924489 | 0.74 | SYK (1.00) | SYKSRCZAP70CDK2 | |
| SCHEMBL13924509 | 0.74 | SYK (1.00) | SYKSRCZAP70CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090048282-A1 | PYRIMIDINE SULFONAMIDE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | WYETH (US) | 2009-02-19 | — | — | US | claimed |
| US-20090048282-A1 | PYRIMIDINE SULFONAMIDE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | WYETH (US) | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048282-A1 | PYRIMIDINE SULFONAMIDE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | WNT1, CTNNB1, WNT3A | SYK 3093/4885SRC 1155/4885ZAP70 1276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.