Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 15/20 | 0.60 |
| ▸ | BCR | P11274 | 13/20 | 0.60 |
| ▸ | PRKCA | P17252 | 8/20 | 0.58 |
| ▸ | EGFR | P00533 | 5/20 | 0.55 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.55 |
| ▸ | SRC | P12931 | 5/20 | 0.55 |
| ▸ | PRKACA | P17612 | 1/20 | 0.55 |
| ▸ | PRKACG | P22612 | 1/20 | 0.55 |
| ▸ | PRKACB | P22694 | 1/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.54 |
| ▸ | KIT | P10721 | 1/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | PRKCG | P05129 | 1/20 | 0.52 |
| ▸ | PRKCB | P05771 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | PRKCH | P24723 | 1/20 | 0.52 |
| ▸ | PRKCI | P41743 | 1/20 | 0.52 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.52 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4151825 | 0.90 | ABL1 (0.52) | ABL1BCRPRKCASRCKIT | |
| SCHEMBL4146823 | 0.85 | IKBKB (0.57) | ABL1BCRPRKCAKITJAK3 | |
| SCHEMBL4154532 | 0.81 | SYK (0.60) | SRCZAP70 | |
| SCHEMBL4150544 | 0.81 | SYK (0.46) | SRCZAP70JAK3 | |
| SCHEMBL4159422 | 0.81 | CDK2 (0.42) | JAK3 | |
| SCHEMBL7471161 | 0.78 | ABL1 (0.68) | ABL1BCRPRKCAEGFRPRKCD | |
| SCHEMBL1978735 | 0.78 | ABL1 (0.69) | ABL1BCRPRKCAEGFRPRKCD | |
| Hydrochloric Acid SCHEMBL2081770 | 0.77 | ABL1 (0.68) | ABL1BCRPRKCAEGFRPRKCD | |
| SCHEMBL4897551 | 0.76 | ABL1 (0.69) | ABL1BCRPRKCAEGFRPRKCD | |
| SCHEMBL7476769 | 0.76 | ABL1 (1.00) | ABL1BCRPRKCAEGFRPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090048282-A1 | PYRIMIDINE SULFONAMIDE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | WYETH (US) | 2009-02-19 | — | — | US | claimed |
| US-20090048282-A1 | PYRIMIDINE SULFONAMIDE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | WYETH (US) | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048282-A1 | PYRIMIDINE SULFONAMIDE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM | WNT1, CTNNB1, WNT3A | ABL1 3340/4885BCR 1159/4885PRKCA 1301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.