SCHEMBL4154540

SCHEMBL4154540

FC(F)(F)Cc1cnc(-c2ccccc2)c2ccccc12

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 1/20 0.50
CYP11B2 P19099 1/20 0.50
ADORA2A P29274 2/20 0.40
TDP1 Q9NUW8 3/20 0.38
MAPK14 Q16539 1/20 0.35
ALDH1A1 P00352 4/20 0.35
NPSR1 Q6W5P4 2/20 0.35
ATM Q13315 1/20 0.35
ADORA1 P30542 1/20 0.35
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
KDM4E B2RXH2 2/20 0.33
CCNK O75909 1/20 0.33
CDK7 P50613 1/20 0.33
CCNH P51946 1/20 0.33
MNAT1 P51948 1/20 0.33
CDK12 Q9NYV4 1/20 0.33
ALPL P05186 1/20 0.33
GAA P10253 1/20 0.33
IDO1 P14902 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3146937 0.74 CYP11B2 (0.43) CYP11B1CYP11B2ADORA2ATDP1ALDH1A1
SCHEMBL27539686 0.73 CYP11B1 (0.50) CYP11B1CYP11B2ADORA2AALDH1A1NPSR1
SCHEMBL2481047 0.71 ADORA2A (0.47) CYP11B1CYP11B2ADORA2ATDP1ALDH1A1
SCHEMBL10300877 0.70 ADORA2A (0.50) CYP11B1CYP11B2ADORA2AALDH1A1NPSR1
SCHEMBL23095358 0.67 ALDH1A1 (0.48) CYP11B1CYP11B2ADORA2AALDH1A1NPSR1
SCHEMBL5548021 0.67 ADORA2A (0.47) CYP11B1CYP11B2ADORA2AALDH1A1NPSR1
SCHEMBL10782921 0.67 ADORA2A (0.47) CYP11B1CYP11B2ADORA2ATDP1ALDH1A1
SCHEMBL7655646 0.67 ADORA2A (0.50) CYP11B1CYP11B2ADORA2AALDH1A1NPSR1
SCHEMBL20809428 0.66 PDE10A (0.33) CYP11B1CYP11B2TDP1ALDH1A1MEN1
SCHEMBL13398384 0.66 CYP11B1 (0.40) CYP11B1CYP11B2TDP1MAPK14ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8920943-B2 Luminescence device and display apparatus CANON KABUSHIKI KAISHA (JP) 2014-12-30 US disclosed
US-20090184634-A1 LUMINESCENCE DEVICE AND DISPLAY APPARATUS CANON KABUSHIKI KAISHA (JP) 2009-07-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090184634-A1 LUMINESCENCE DEVICE AND DISPLAY APPARATUS SOD1, NLRP1, LUC7L2 CYP11B1 3868/4885CYP11B2 3728/4885ADORA2A 1882/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.