SCHEMBL4154665

SCHEMBL4154665

Cc1ccccc1-c1c(F)c(F)c(F)c(F)c1F

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 2/20 0.46
TSHR P16473 2/20 0.43
NPC1 O15118 3/20 0.41
RAB9A P51151 3/20 0.41
SMN1; SMN2 Q16637 3/20 0.41
CASP3 P42574 1/20 0.41
SENP8 Q96LD8 1/20 0.41
SENP7 Q9BQF6 1/20 0.41
SENP6 Q9GZR1 1/20 0.41
GAA P10253 2/20 0.39
HEXA P06865 1/20 0.38
HEXB P07686 1/20 0.38
HTT P42858 1/20 0.37
KDM4C Q9H3R0 1/20 0.37
MYC P01106 1/20 0.36
IDO1 P14902 1/20 0.36
METAP2 P50579 1/20 0.36
PDK2 Q15119 1/20 0.36
ALDH1A1 P00352 2/20 0.35
CA1 P00915 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10344370 0.85 ACHE (0.38) ACHETSHRNPC1RAB9ASMN1; SMN2
SCHEMBL22036106 0.82 LMNA (0.44) ACHETSHRNPC1RAB9ASMN1; SMN2
SCHEMBL25223032 0.81 MEN1 (0.35) TSHRNPC1RAB9ASMN1; SMN2HTT
SCHEMBL10765844 0.80 GCGR (0.35) ACHETSHRNPC1RAB9ASMN1; SMN2
SCHEMBL16127355 0.78 CD44 (0.46) ACHETSHRNPC1RAB9ASMN1; SMN2
SCHEMBL12999231 0.78 ALDH1A1 (0.37) ACHETSHRNPC1RAB9ASMN1; SMN2
SCHEMBL16222498 0.77 ACHE (0.33) ACHETSHR
SCHEMBL2941073 0.76 HEXA (0.40) ACHETSHRNPC1RAB9ASMN1; SMN2
SCHEMBL1133067 0.76 MYC (0.56) ACHETSHRNPC1RAB9ASMN1; SMN2
SCHEMBL12887878 0.75 MEN1 (0.35) ACHETSHRNPC1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230309388-A1 ORGANIC ELECTROLUMINESCENT MATERIAL AND DEVICE Beijing Summer Sprout Technology Co., Ltd. (CN) 2023-09-28 US disclosed
WO-2017193288-A1 SYNTHESIS OF PHOSPHINE LIGANDS BEARING TUNABLE LINKAGE: METHODS OF THEIR USE IN CATALYSIS THE HONG KONG POLYTECHNIC UNIVERSITY SHENZHEN RESEARCH INSTITUTE (CN) 2017-11-16 WO disclosed
US-8952207-B2 Copper-catalyzed C—H bond arylation THE UNIVERSITY OF HOUSTON SYSTEM (US) 2015-02-10 US disclosed
US-20090076266-A1 COPPER-CATALYZED C-H BOND ARYLATION THE UNIVERSITY OF HOUSTON SYSTEM (US) 2009-03-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090076266-A1 COPPER-CATALYZED C-H BOND ARYLATION AOC2, AOC3, DBH ACHE 3552/4885TSHR 3189/4885NPC1 1325/4885
US-20230309388-A1 ORGANIC ELECTROLUMINESCENT MATERIAL AND DEVICE OCIAD1, OCIAD2, SLCO4C1 ACHE 1667/4885TSHR 4318/4885NPC1 967/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.