Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.72 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.58 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.50 |
| ▸ | RELA | Q04206 | 2/20 | 0.50 |
| ▸ | NCF1 | P14598 | 1/20 | 0.50 |
| ▸ | AR | P10275 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28516025 | 0.84 | ACHE (0.93) | ACHEALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL2873300 | 0.84 | ACHE (1.00) | ACHEALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL29726808 | 0.81 | ACACA (0.65) | ACHECYP1A1CYP1B1CYP1A2ALDH1A1 | |
| SCHEMBL28905536 | 0.81 | ACHE (0.73) | ACHEALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL6534364 | 0.80 | CYP1A1 (0.50) | ACHECYP1A1CYP1B1CYP1A2ALDH1A1 | |
| SCHEMBL3879052 | 0.80 | ALDH1A1 (0.57) | ACHECYP1A1CYP1B1CYP1A2ALDH1A1 | |
| SCHEMBL15919363 | 0.80 | ACHE (0.77) | ACHECYP1A1CYP1B1CYP1A2ALDH1A1 | |
| SCHEMBL4143397 | 0.80 | ACHE (0.77) | ACHECYP1A1CYP1B1CYP1A2ALDH1A1 | |
| SCHEMBL6755822 | 0.80 | MEN1 (0.51) | ACHECYP1A1CYP1B1CYP1A2ALDH1A1 | |
| SCHEMBL31134275 | 0.80 | CYP1A1 (0.50) | ACHECYP1A1CYP1B1CYP1A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9102937-B2 | Stable and selective formation of hoogsteen-type triplexes and duplexes using twisted intercalating nucleic acids (TINA) and process for the preparation of TINA | TINA HOLDING APS (DK) | 2015-08-11 | — | — | US | disclosed |
| CN-101238213-B | Stable and selective formation of hoogsteen-type triplexes and duplexes using twisted intercalating nucleic acids (TINA) and process for the preparation of tina | TINA HOLDING APS | 2015-05-20 | — | — | CN | disclosed |
| EP-1888748-B1 | STABLE AND SELECTIVE FORMATION OF HOOGSTEEN-TYPE TRIPLEXES AND DUPLEXES USING TWISTED INTERCALATING NUCLEIC ACIDS (TINA) AND PROCESS FOR THE PREPARATION OF TINA | TINA HOLDING APS (DK) | 2013-08-28 | — | — | EP | disclosed |
| US-20090216003-A1 | STABLE AND SELECTIVE FORMATION OF HOOGSTEEN-TYPE TRIPLEXES AND DUPLEXES USING TWISTED INTERCALATING NUCLEIC ACIDS (TINA) AND PROCESS FOR THE PREPARATION OF TINA | TINA HOLDING APS (DK) | 2009-08-27 | — | — | US | disclosed |
| US-20090069338-A1 | Method for predicting skin sensitizing activity of compounds | DICKSON JR JOHN K | 2009-03-12 | — | — | US | disclosed |
| US-7452887-B2 | Quinoline- and isoquinoline-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof | AMPHORA DISCOVERY CORPORATION (US) | 2008-11-18 | — | — | US | disclosed |
| CN-101238213-A | Stable and selective formation of hoogsteen-type triplexes and duplexes using twisted intercalating nucleic acids (TINA) and process for the preparation of tina | TINA HOLDING APS (DK) | 2008-08-06 | — | — | CN | disclosed |
| EP-1888748-A2 | STABLE AND SELECTIVE FORMATION OF HOOGSTEEN-TYPE TRIPLEXES AND DUPLEXES USING TWISTED INTERCALATING NUCLEIC ACIDS (TINA) AND PROCESS FOR THE PREPARATION OF TINA | Tina Holding ApS (DK) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006125447-A2 | STABLE AND SELECTIVE FORMATION OF HOOGSTEEN-TYPE TRIPLEXES AND DUPLEXES USING TWISTED INTERCALATING NUCLEIC ACIDS (TINA) AND PROCESS FOR THE PREPARATION OF TINA | TINA HOLDING APS (DK) | 2006-11-30 | — | — | WO | disclosed |
| US-20060009460-A1 | Quinoline- and isoquinoline-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof | AGRIUS GROUP, LLC. | 2006-01-12 | — | — | US | disclosed |
| EP-1377554-A1 | ANTAGONISM OF IMMUNOSTIMULATORY CPG-OLIGONUCLEOTIDES BY 4-AMINOQUINOLINES AND OTHER WEAK BASES | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2004-01-07 | — | — | EP | disclosed |
| US-6479504-B1 | USED IN PREVENTATIVE AND THERAPEUTIC TREATMENTS OF AUTOIMMUNE DISEASES AND PHENOMENA, TRANSPLANT REJECTION SUCH AS HOST-VERSUS-GRAFT DISEASE, AND SEPSIS | THE UNIVERSITY OF IOWA RESEARCH FOUNDATION | 2002-11-12 | — | — | US | disclosed |
| WO-2000076982-A1 | ANTAGONISM OF IMMUNOSTIMULATORY CPG-OLIGONUCLEOTIDES BY 4-AMINOQUINOLINES AND OTHER WEAK BASES | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2000-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069338-A1 | Method for predicting skin sensitizing activity of compounds | ATP5ME, ABCG2, ATP5MG | ACHE 31/4885CYP1A1 72/4885CYP1B1 171/4885 |
| US-20060009460-A1 | Quinoline- and isoquinoline-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof | ATP5ME, ATP5MG, ATP5MK | ACHE 12/4885CYP1A1 252/4885CYP1B1 320/4885 |
| US-20090216003-A1 | STABLE AND SELECTIVE FORMATION OF HOOGSTEEN-TYPE TRIPLEXES AND DUPLEXES USING TWISTED INTERCALATING NUCLEIC ACIDS (TINA) AND PROCESS FOR THE PREPARATION OF TINA | PCNA, DNA2, NUDT1 | ACHE 4762/4885CYP1A1 4312/4885CYP1B1 4351/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.