SCHEMBL4156068

SCHEMBL4156068

COc1cccc(I)c1OC

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.50
CA12 O43570 2/20 0.48
CA1 P00915 2/20 0.48
CA2 P00918 2/20 0.48
CA7 P43166 2/20 0.48
CA9 Q16790 2/20 0.48
CA14 Q9ULX7 2/20 0.48
CA4 P22748 1/20 0.48
NFE2L2 Q16236 5/20 0.44
MAPK1 P28482 2/20 0.43
KDM4E B2RXH2 2/20 0.43
MAPT P10636 2/20 0.43
HSD17B10 Q99714 2/20 0.43
ALDH1A1 P00352 1/20 0.43
LMNA P02545 1/20 0.43
TP53 P04637 1/20 0.43
CYP3A4 P08684 1/20 0.43
HPGD P15428 1/20 0.43
ALOX15 P16050 1/20 0.43
ALOX12 P18054 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30350539 1.00 SMN1; SMN2 (0.50) SMN1; SMN2CA12CA1CA2CA7
Cyanide SCHEMBL27389366 0.94 SMN1; SMN2 (0.45) SMN1; SMN2CA12CA1CA2CA7
SCHEMBL9376529 0.92 SMN1; SMN2 (0.44) SMN1; SMN2CA12CA1CA2CA7
SCHEMBL3648629 0.85 SMN1; SMN2 (0.46) SMN1; SMN2CA12CA1CA2CA7
SCHEMBL25434306 0.82 CA1 (0.61) SMN1; SMN2CA12CA1CA2CA7
SCHEMBL151213 0.82 CA1 (0.61) SMN1; SMN2CA12CA1CA2CA7
SCHEMBL27753904 0.82 CA1 (0.61) SMN1; SMN2CA12CA1CA2CA7
SCHEMBL3711484 0.80 SMN1; SMN2 (0.50) SMN1; SMN2CA12CA1CA2CA7
SCHEMBL22588491 0.80 MAPK1 (0.48) SMN1; SMN2CA12CA1CA2CA7
Hydrochloric Acid SCHEMBL31658961 0.79 SMN1; SMN2 (0.58) SMN1; SMN2CA12CA1CA2CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12398152-B2 Thioxanthone derivatives, composition comprising the same and pattern forming method comprising said composition LINTFIELD LIMITED (GB) 2025-08-26 US disclosed
US-20230192622-A1 ANTI-SARS-COV-2 DRUG ONCOLYS BIOPHARMA, INC. (JP) 2023-06-22 US disclosed
US-20230192622-A1 ANTI-SARS-COV-2 DRUG ONCOLYS BIOPHARMA, INC. (JP) 2023-06-22 US disclosed
CN-107567443-B Biaryl derivatives as GPR120 agonists 株式会社LG化学 2023-04-28 CN disclosed
CN-115925679-A Biaryl derivatives as GPR120 agonists 株式会社LG化学 2023-04-07 CN disclosed
EP-4154884-A1 ANTI-SARS-COV-2 DURG Oncolys BioPharma, Inc. (JP) 2023-03-29 EP disclosed
EP-3239143-B1 BIARYL DERIVATIVE AS GPR120 AGONIST LG CHEMICAL LTD (KR) 2023-03-22 EP disclosed
US-20220135574-A1 BIARYL DERIVATIVE AS GPR120 AGONIST LG CHEM, LTD. (KR) 2022-05-05 US disclosed
US-11261186-B2 Biaryl derivative as GPR120 agonist LG CHEM. LTD. (KR) 2022-03-01 US disclosed
US-20210277017-A1 Thioxanthone Derivatives, Composition Comprising the Same and Pattern Forming Method Comprising Said Composition LINTFIELD LIMITED (GB) 2021-09-09 US disclosed
US-6048842-A ANTIDIABETIC AGENT TANABE SEIYAKU CO., LTD. (JP) 2000-04-11 US disclosed
US-RE36256-E ADMINISTERING ARYL-SUBSTITUTED QUINOXALINE DERIVATIVES AS ANTIPROLIFERATIVE, ANTICARCINOGENIC AND ANTITUMOR AGENTS RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) 1999-07-20 US disclosed
US-5795889-A INHIBITING CELL GROWTH WITH ENZYME INHIBITORS FOR SKIN DISORDERS RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 1998-08-18 US disclosed
EP-0850948-A1 Propiophenone derivatives and process for preparing the same TANABE SEIYAKU CO., LTD. (JP) 1998-07-01 EP disclosed
EP-0584222-B1 BIS MONO-AND BICYCLIC ARYL AND HETEROARYL COMPOUNDS WHICH INHIBIT EGF AND/OR PDGF RECEPTOR TYROSINE KINASE RHONE POULENC RORER INT (US) 1997-10-08 EP disclosed
US-5656643-A QUINOLIN PYRIDINE DERIVATIVES; USEFUL FOR TREATING CANCER, LEKEMIA, PSORIASIS, INFLAMMATORY DISODERS, BONE DISORDERS, ATHEROSCLEROSIS AND RESTENOSIS; CONTROLLS CELLULAR REPRODUCTION RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 1997-08-12 US disclosed
US-5646153-A INHIBITING ABNORMAL CELL PROLIFERATION RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 1997-07-08 US disclosed
US-5480883-A Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 1996-01-02 US disclosed
US-5409930-A Inhibits abnoramal cell proliferation; dimethoxyquinoline/ dimethylquinoline/ quinolineoxide/ and quinoxaline derivatives RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 1995-04-25 US disclosed
WO-1992020642-A1 BIS MONO-AND BICYCLIC ARYL AND HETEROARYL COMPOUNDS WHICH INHIBIT EGF AND/OR PDGF RECEPTOR TYROSINE KINASE RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) 1992-11-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230192622-A1 ANTI-SARS-COV-2 DRUG ACE2, ACE, SARS1 SMN1; SMN2 4289/4885CA12 1337/4885CA1 4223/4885
US-12398152-B2 Thioxanthone derivatives, composition comprising the same and pattern forming method comprising said composition TPMT, TST, PPOX SMN1; SMN2 4881/4885CA12 2777/4885CA1 3798/4885
US-20220135574-A1 BIARYL DERIVATIVE AS GPR120 AGONIST GPR119, GLP1R, GIPR SMN1; SMN2 3448/4885CA12 4663/4885CA1 4658/4885
US-11261186-B2 Biaryl derivative as GPR120 agonist GPR119, GPR88, FFAR1 SMN1; SMN2 4496/4885CA12 4774/4885CA1 4805/4885
US-20210277017-A1 Thioxanthone Derivatives, Composition Comprising the Same and Pattern Forming Method Comprising Said Composition TPMT, TST, PPOX SMN1; SMN2 4881/4885CA12 2777/4885CA1 3798/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.