Sugi Predict

Sugi Predict / Compounds / SCHEMBL4157253

SCHEMBL4157253

SCHEMBL4157253

FC(F)(F)c1ccc(-c2nc3ccccc3o2)cc1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PTPN2 P17706 5/20 0.68
▸ PTPN1 P18031 5/20 0.68
▸ PTPN5 P54829 5/20 0.68
▸ HSPD1 P10809 4/20 0.68
▸ HSPE1 P61604 4/20 0.68
▸ NPC1 O15118 6/20 0.63
▸ RAB9A P51151 4/20 0.63
▸ MEN1 O00255 2/20 0.63
▸ KMT2A Q03164 2/20 0.63
▸ ATM Q13315 1/20 0.63
▸ ALDH1A1 P00352 3/20 0.58
▸ HSD17B10 Q99714 3/20 0.58
▸ KDM4E B2RXH2 2/20 0.58
▸ HPGD P15428 2/20 0.58
▸ SMN1; SMN2 Q16637 2/20 0.58
▸ TP53 P04637 1/20 0.58
▸ MMP2 P08253 1/20 0.55
▸ MMP9 P14780 1/20 0.55
▸ MMP8 P22894 1/20 0.55
▸ MMP13 P45452 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24038147 0.91 PTPN2 (0.60) PTPN2PTPN1PTPN5HSPD1HSPE1
SCHEMBL24038217 0.91 PTPN2 (0.60) PTPN2PTPN1PTPN5HSPD1HSPE1
SCHEMBL24037786 0.91 PTPN2 (0.60) PTPN2PTPN1PTPN5HSPD1HSPE1
SCHEMBL26818922 0.88 P2RY14 (0.59) PTPN2PTPN1PTPN5HSPD1HSPE1
SCHEMBL15479608 0.87 NPC1 (0.59) PTPN2PTPN1PTPN5HSPD1HSPE1
SCHEMBL24038091 0.87 PTPN2 (0.56) PTPN2PTPN1PTPN5HSPD1HSPE1
SCHEMBL31170 0.86 NPC1 (0.81) PTPN2PTPN1PTPN5NPC1RAB9A
SCHEMBL26818750 0.85 PTPN2 (0.63) PTPN2PTPN1PTPN5HSPD1HSPE1
SCHEMBL31476 0.84 NPC1 (0.79) PTPN2PTPN1PTPN5NPC1RAB9A
Methane SCHEMBL29265168 0.84 NPC1 (0.79) PTPN2PTPN1PTPN5NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118373784-B One-pot preparation method of 2-aryl benzoxazole and asymmetric sulfoxide 江苏师范大学 2024-09-03 — — CN disclosed
CN-118373784-A One-pot preparation method of 2-aryl benzoxazole and asymmetric sulfoxide 江苏师范大学 2024-07-23 — — CN disclosed
US-20230255906-A1 Targeting Serpin B9 in Cancer THE BRIGHAM AND WOMEN'S HOSPITAL, INC. 2023-08-17 — — US disclosed
US-20200275655-A1 PYRIDINIUM SALT AND PEST CONTROL AGENT NIPPON SODA CO., LTD. (JP) 2020-09-03 — — US disclosed
EP-2774923-B1 METHOD FOR PRODUCING PHENYL-SUBSTITUTED HETEROCYCLIC DERIVATIVE UNIV NAGOYA NAT UNIV CORP (JP) 2016-05-18 — — EP disclosed
US-8993777-B2 Method for producing phenyl-substituted heterocyclic derivative NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (JP) 2015-03-31 — — US disclosed
US-8993777-B2 Method for producing phenyl-substituted heterocyclic derivative NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (JP) 2015-03-31 — — US disclosed
US-8993777-B2 Method for producing phenyl-substituted heterocyclic derivative NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (JP) 2015-03-31 — — US disclosed
US-8952207-B2 Copper-catalyzed C—H bond arylation THE UNIVERSITY OF HOUSTON SYSTEM (US) 2015-02-10 — — US disclosed
US-8952207-B2 Copper-catalyzed C—H bond arylation THE UNIVERSITY OF HOUSTON SYSTEM (US) 2015-02-10 — — US disclosed
US-8952207-B2 Copper-catalyzed C—H bond arylation THE UNIVERSITY OF HOUSTON SYSTEM (US) 2015-02-10 — — US disclosed
US-20140275549-A1 METHOD FOR PRODUCING PHENYL-SUBSTITUTED HETEROCYCLIC DERIVATIVE NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (JP) 2014-09-18 — — US disclosed
US-20140275549-A1 METHOD FOR PRODUCING PHENYL-SUBSTITUTED HETEROCYCLIC DERIVATIVE NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (JP) 2014-09-18 — — US disclosed
US-20140275549-A1 METHOD FOR PRODUCING PHENYL-SUBSTITUTED HETEROCYCLIC DERIVATIVE NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (JP) 2014-09-18 — — US disclosed
EP-2774923-A1 METHOD FOR PRODUCING PHENYL-SUBSTITUTED HETEROCYCLIC DERIVATIVE National University Corporation Nagoya University (JP) 2014-09-10 — — EP disclosed
EP-2774923-A1 METHOD FOR PRODUCING PHENYL-SUBSTITUTED HETEROCYCLIC DERIVATIVE National University Corporation Nagoya University (JP) 2014-09-10 — — EP disclosed
US-20090076266-A1 COPPER-CATALYZED C-H BOND ARYLATION THE UNIVERSITY OF HOUSTON SYSTEM (US) 2009-03-19 — — US disclosed
US-20090076266-A1 COPPER-CATALYZED C-H BOND ARYLATION THE UNIVERSITY OF HOUSTON SYSTEM (US) 2009-03-19 — — US disclosed
US-20090076266-A1 COPPER-CATALYZED C-H BOND ARYLATION THE UNIVERSITY OF HOUSTON SYSTEM (US) 2009-03-19 — — US disclosed
US-20060258723-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds PFIZER INC 2006-11-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200275655-A1 PYRIDINIUM SALT AND PEST CONTROL AGENT PRDX1, KCNQ5, KCNQ1 PTPN2 68/4885PTPN1 63/4885PTPN5 38/4885
US-20060258723-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds PPARG, PPARA, PPARD PTPN2 2602/4885PTPN1 2278/4885PTPN5 2417/4885
US-20140275549-A1 METHOD FOR PRODUCING PHENYL-SUBSTITUTED HETEROCYCLIC DERIVATIVE PAH, DDT, NISCH PTPN2 2283/4885PTPN1 2525/4885PTPN5 2499/4885
US-20090076266-A1 COPPER-CATALYZED C-H BOND ARYLATION AOC2, AOC3, DBH PTPN2 2239/4885PTPN1 2463/4885PTPN5 3003/4885
US-20230255906-A1 Targeting Serpin B9 in Cancer SERPINB10, SERPINB8, SERPINE1 PTPN2 4455/4885PTPN1 4551/4885PTPN5 4510/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.