Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.68 |
| ▸ | RAB9A | P51151 | 4/20 | 0.68 |
| ▸ | PKM | P14618 | 4/20 | 0.56 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3290802 | 0.82 | NPC1 (0.74) | NPC1RAB9APKMCYP11B2KMT2A | |
| SCHEMBL4188221 | 0.81 | NPC1 (1.00) | NPC1RAB9APKMCYP11B2KMT2A | |
| SCHEMBL29874794 | 0.81 | NPC1 (1.00) | NPC1RAB9APKMCYP11B2KMT2A | |
| SCHEMBL28582028 | 0.81 | NPC1 (0.42) | NPC1RAB9APKMCYP11B2KMT2A | |
| Hydrochloric Acid SCHEMBL31529590 | 0.80 | NPC1 (0.96) | NPC1RAB9APKMCYP11B2KMT2A | |
| Acetic Acid SCHEMBL3681231 | 0.74 | NPC1 (0.83) | NPC1RAB9APKMCYP11B2KMT2A | |
| SCHEMBL27265234 | 0.73 | HTT (0.49) | RAB9AKMT2AGAAMEN1HTT | |
| SCHEMBL14542411 | 0.72 | NPC1 (0.74) | NPC1RAB9APKMCYP11B2KMT2A | |
| SCHEMBL11255826 | 0.72 | NPC1 (0.74) | NPC1RAB9APKMCYP11B2KMT2A | |
| SCHEMBL17131794 | 0.72 | NPC1 (0.74) | NPC1RAB9APKMCYP11B2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090030083-A1 | Use of n-(2-aryl-propionyl)-sulfonamides for the treatment of spinal cord injury | DOMPE' PHA.R.MA S.P.A (IT) | 2009-01-29 | — | — | US | claimed |
| EP-1579859-B1 | Use of N-(2-aryl-propionyl)-sulfonamides for the treatment of spinal cord injury | DOMPE PHA R MA SPA RES & MFG (IT) | 2006-12-13 | — | — | EP | claimed |
| WO-2005092315-A1 | USE OF N-(2-ARYL-PROPIONYL)-SULFONAMIDES FOR THE TREATMENT OF SPINAL CORD INJURY | DOMPE' PHA.R.MA S.P.A. (IT) | 2005-10-06 | — | — | WO | claimed |
| EP-1579859-A1 | Use of N-(2-aryl-propionyl)-sulfonamides for the treatment of spinal cord injury | Dompe' S.P.A. (IT) | 2005-09-28 | — | — | EP | claimed |
| JP-53127463-A | — | — | None | — | — | JP | disclosed |
| US-9328057-B2 | Chiral arylketones in the treatment of neutrophil-dependent inflammatory diseases | DOMPE' FARMACEUTICI S.P.A. (IT) | 2016-05-03 | — | — | US | disclosed |
| US-20090203652-A1 | CHIRAL ARYLKETONES IN THE TREATMENT OF NEUTROPHIL-DEPENDENT INFLAMMATORY DISEASES | DOMPE PHA.R.MA S.P.A. (IT) | 2009-08-13 | — | — | US | disclosed |
| US-20090030083-A1 | Use of n-(2-aryl-propionyl)-sulfonamides for the treatment of spinal cord injury | DOMPE' PHA.R.MA S.P.A (IT) | 2009-01-29 | — | — | US | disclosed |
| EP-1581474-B1 | CHIRAL ARYLKETONES IN THE TREATEMENT OF NEUTROPHIL-DEPENDENT INFLAMMATORY DESEASES | DOMPE SPA (IT) | 2008-08-27 | — | — | EP | disclosed |
| EP-1579859-B1 | Use of N-(2-aryl-propionyl)-sulfonamides for the treatment of spinal cord injury | DOMPE PHA R MA SPA RES & MFG (IT) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005092315-A1 | USE OF N-(2-ARYL-PROPIONYL)-SULFONAMIDES FOR THE TREATMENT OF SPINAL CORD INJURY | DOMPE' PHA.R.MA S.P.A. (IT) | 2005-10-06 | — | — | WO | disclosed |
| EP-1581474-A1 | CHIRAL ARYLKETONES IN THE TREATEMENT OF NEUTROPHIL-DEPENDENT INFLAMMATORY DESEASES | Dompé S.P.A. (IT) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004052830-A1 | CHIRAL ARYLKETONES IN THE TREATEMENT OF NEUTROPHIL-DEPENDENT INFLAMMATORY DESEASES | DOMPE S.P.A. (IT) | 2004-06-24 | — | — | WO | disclosed |
| US-20030216392-A1 | N - ( 2 - aryl - propionyl ) - sulfonamides and pharmaceutical preparations containing them | DOMPE S.P.A. | 2003-11-20 | — | — | US | disclosed |
| EP-1123276-B1 | N-(2-ARYL-PROPIONYL)-SULFONAMIDES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | DOMPE SPA (IT) | 2003-01-08 | — | — | EP | disclosed |
| EP-1123276-A1 | N-(2-ARYL-PROPIONYL)-SULFONAMIDES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | Dompe' S.P.A. (IT) | 2001-08-16 | — | — | EP | disclosed |
| WO-2000024710-A1 | N-(2-ARYL-PROPIONYL)-SULFONAMIDES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | DOMPE' S.P.A. (IT) | 2000-05-04 | — | — | WO | disclosed |
| CN-1017527-B | Process for preparing optically active oxoisoindolinyl derivatives | ERBA FARMITALIA (IT) | 1992-07-22 | — | — | CN | disclosed |
| CN-88101200-A | The preparation method of the oxo-isoindolinyl derivatives of optically-active | — | 1988-10-26 | — | — | CN | disclosed |
| JP-S53127463-A | 2-(4-(1-OXO-2-ISOINDOLINYL)PHENYL) PROPYLALDEHYDE AND ITS PREPARATION | GRELAN PHARMACEUT CO LTD | 1978-11-07 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090030083-A1 | Use of n-(2-aryl-propionyl)-sulfonamides for the treatment of spinal cord injury | PMP22, SMN1; SMN2, PLP2 | NPC1 4503/4885RAB9A 3512/4885PKM 3410/4885 |
| US-20030216392-A1 | N - ( 2 - aryl - propionyl ) - sulfonamides and pharmaceutical preparations containing them | ELANE, MPO, FPR1 | NPC1 1760/4885RAB9A 2055/4885PKM 4195/4885 |
| US-20090203652-A1 | CHIRAL ARYLKETONES IN THE TREATMENT OF NEUTROPHIL-DEPENDENT INFLAMMATORY DISEASES | NR1H4, MMP8, NR1I2 | NPC1 590/4885RAB9A 904/4885PKM 1408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.