Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.74 |
| ▸ | RAB9A | P51151 | 5/20 | 0.74 |
| ▸ | PKM | P14618 | 4/20 | 0.66 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.54 |
| ▸ | RELA | Q04206 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | PGR | P06401 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | DRD1 | P21728 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4188221 | 0.85 | NPC1 (1.00) | NPC1RAB9APKMCYP11B2SMN1; SMN2 | |
| SCHEMBL29874794 | 0.85 | NPC1 (1.00) | NPC1RAB9APKMCYP11B2SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL31529590 | 0.84 | NPC1 (0.96) | NPC1RAB9APKMCYP11B2SMN1; SMN2 | |
| SCHEMBL4157597 | 0.82 | NPC1 (0.68) | NPC1RAB9APKMCYP11B2SMN1; SMN2 | |
| SCHEMBL30910321 | 0.79 | NPC1 (0.74) | NPC1RAB9APKMCYP11B2SMN1; SMN2 | |
| SCHEMBL11255826 | 0.79 | NPC1 (0.74) | NPC1RAB9APKMCYP11B2SMN1; SMN2 | |
| SCHEMBL17131794 | 0.79 | NPC1 (0.74) | NPC1RAB9APKMCYP11B2SMN1; SMN2 | |
| SCHEMBL4150687 | 0.79 | NPC1 (0.74) | NPC1RAB9APKMCYP11B2SMN1; SMN2 | |
| SCHEMBL14542411 | 0.79 | NPC1 (0.74) | NPC1RAB9APKMCYP11B2SMN1; SMN2 | |
| SCHEMBL28356711 | 0.79 | NPC1 (0.74) | NPC1RAB9APKMCYP11B2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648886-B1 | BENZOXAZINONE-DERIVED SULFONAMIDE COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS | ESTEVE LABOR DR (ES) | 2009-12-09 | — | — | EP | claimed |
| US-20060247297-A1 | Chiral arylketones in the treatment of neutrophil-dependent inflammatory diseases | DOMPE PHA.R.MA S.P.A. (IT) | 2006-11-02 | — | — | US | claimed |
| US-6683205-B2 | FROM ARYLCARBOXYALDEHYDES OR 2-ARYL-3-HYDROXYPROPENOIC ACIDS | WISYS TECHNOLOGY FOUNDATION, INC. | 2004-01-27 | — | — | US | claimed |
| US-20020120153-A1 | Synthesis of 2-aryl propenoic acid esters for the production of non-steroidal anti-inflammatory drugs | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2002-08-29 | — | — | US | claimed |
| EP-0151702-B1 | ALPHA-HYDROXYKETONE ACETALS | SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) | 1987-11-25 | — | — | EP | claimed |
| EP-0151702-A2 | Alpha-hydroxyketone acetals | SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) | 1985-08-21 | — | — | EP | claimed |
| EP-0048136-A2 | Process for preparing alpha-aromatic group substituted alkanoic acids or esters thereof | SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) | 1982-03-24 | — | — | EP | claimed |
| JP-52156856-A | — | — | None | — | — | JP | disclosed |
| JP-53090257-A | — | — | None | — | — | JP | disclosed |
| US-10610515-B2 | Composition including indoprofen and use thereof | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2020-04-07 | — | — | US | disclosed |
| US-20170095451-A1 | COMPOSITION INCLUDING INDOPROFEN AND USE THEREOF | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2017-04-06 | — | — | US | disclosed |
| US-9315442-B2 | Method for manufacturing optically active carboxylic acid ester | TOKYO UNIVERSITY OF SCIENCE EDUCATIONAL FOUNDATION ADMINISTRATIVE ORGANIZATION (JP) | 2016-04-19 | — | — | US | disclosed |
| US-20140135520-A1 | METHOD FOR MANUFACTURING OPTICALLY ACTIVE CARBOXYLIC ACID ESTER | Tokyo University of Science Educational Foundation Administration Organization (JP) | 2014-05-15 | — | — | US | disclosed |
| US-5273895-A | Oxidizing the aldehyde or hydroxy precursor by an enzyme or Pseudomonas, Aeromonas, Escherichia and Alicaligenes | SEPRACOR, INC. (US) | 1993-12-28 | — | — | US | disclosed |
| US-4778799-A | ANALGESIC, ANTIPYRETIC, ANTIINFLAMMATORY AGENT | TIBES ULRICH (DE) | 1988-10-18 | — | — | US | disclosed |
| EP-0151702-B1 | ALPHA-HYDROXYKETONE ACETALS | SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) | 1987-11-25 | — | — | EP | disclosed |
| US-4362738-A | ANTIINFLAMMATORIES | DR. KARL THOMAE GMBH (DE) | 1982-12-07 | — | — | US | disclosed |
| EP-0024282-A1 | Benzoyl derivatives, their preparation and their use as medicines | Dr. Karl Thomae GmbH (DE) | 1981-03-04 | — | — | EP | disclosed |
| JP-S5390257-A | 1-(4-(1-OXO-2-ISOINDOLINYL)PHENYL) ETHANOL DERIVS. AND PROCESS FOR THEIR PREPARATION | GRELAN PHARMACEUT CO LTD | 1978-08-08 | — | — | JP | disclosed |
| JP-S52156856-A | 2-CYANO-3-METHYL-3-#4-(1-OXO-2-ISOINDOLINYL)PHENYL#ACRYLIC ACIDS AND THEIR PREPARATION | GRELAN PHARMACEUT CO LTD | 1977-12-27 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170095451-A1 | COMPOSITION INCLUDING INDOPROFEN AND USE THEREOF | NCOA3, NCOA1, PPARG | NPC1 1279/4885RAB9A 4556/4885PKM 671/4885 |
| US-10610515-B2 | Composition including indoprofen and use thereof | NCOA3, NCOA1, PPARG | NPC1 1279/4885RAB9A 4556/4885PKM 671/4885 |
| US-20060247297-A1 | Chiral arylketones in the treatment of neutrophil-dependent inflammatory diseases | NR1H4, MMP8, NR1I2 | NPC1 590/4885RAB9A 904/4885PKM 1408/4885 |
| US-20140135520-A1 | METHOD FOR MANUFACTURING OPTICALLY ACTIVE CARBOXYLIC ACID ESTER | ALDH1A2, ADH1C, ADH1A | NPC1 4636/4885RAB9A 851/4885PKM 679/4885 |
| US-20020120153-A1 | Synthesis of 2-aryl propenoic acid esters for the production of non-steroidal anti-inflammatory drugs | ALOX15, ALOX15B, ALOX5 | NPC1 1629/4885RAB9A 2813/4885PKM 3262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.