Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 6/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.44 |
| ▸ | LCK | P06239 | 4/20 | 0.42 |
| ▸ | KDR | P35968 | 4/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.42 |
| ▸ | JAK3 | P52333 | 3/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 6/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4165746 | 0.90 | ALDH1A1 (0.44) | ALDH1A1SCN5ASCN9ALCKKDR | |
| SCHEMBL4158189 | 0.72 | PARP1 (0.43) | SCN9A | |
| SCHEMBL4306073 | 0.71 | NR1H2 (0.37) | — | |
| SCHEMBL28235432 | 0.71 | PSMD14 (0.60) | — | |
| SCHEMBL11499102 | 0.70 | HPGDS (0.54) | BRAF | |
| SCHEMBL7451848 | 0.70 | PSMD14 (0.61) | SCN9A | |
| SCHEMBL2452806 | 0.70 | CA1 (0.41) | SCN9A | |
| SCHEMBL10871494 | 0.69 | PSMD14 (0.69) | — | |
| SCHEMBL31124478 | 0.67 | PSMD14 (0.43) | BRAF | |
| SCHEMBL17934555 | 0.67 | ALDH1A1 (0.61) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |