Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 6/20 | 0.47 |
| ▸ | JAK1 | P23458 | 6/20 | 0.47 |
| ▸ | JAK3 | P52333 | 5/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 4/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4010236 | 0.94 | JAK2 (0.51) | MAP3K11KDM4EHSD17B10RECQLJAK2 | |
| SCHEMBL3924773 | 0.86 | EGFR (0.48) | KDM4EHSD17B10RECQLJAK2JAK1 | |
| SCHEMBL3928126 | 0.85 | MCHR1 (0.47) | MAP3K11KDM4EHSD17B10RECQLADORA2A | |
| SCHEMBL4297778 | 0.82 | ATR (0.58) | MAP3K11JAK2JAK1JAK3KIT | |
| SCHEMBL4139890 | 0.82 | KDM4E (0.50) | KDM4EHSD17B10RECQLEGFRALDH1A1 | |
| SCHEMBL4006573 | 0.75 | ATR (0.59) | EGFR | |
| SCHEMBL2801860 | 0.75 | JAK2 (0.59) | MAP3K11JAK2JAK1JAK3KIT | |
| SCHEMBL18832177 | 0.72 | KIT (0.59) | MAP3K11KITPDPK1ADORA2A | |
| SCHEMBL30505753 | 0.72 | KIT (0.59) | MAP3K11KITPDPK1ADORA2A | |
| SCHEMBL2799644 | 0.71 | JAK2 (0.64) | MAP3K11KDM4EJAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007390-A2 | 2-PYRAZ INYLBENZ IMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | claimed |