Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 17/20 | 0.59 |
| ▸ | ACHE | P22303 | 2/20 | 0.53 |
| ▸ | PRKDC | P78527 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4297778 | 0.93 | ATR (0.58) | ATRPRKDCATMEGFR | |
| SCHEMBL3927916 | 0.90 | ATR (0.48) | ATR | |
| SCHEMBL4009811 | 0.90 | MCHR1 (0.49) | ATR | |
| SCHEMBL4012928 | 0.89 | ATR (0.54) | ATR | |
| SCHEMBL4009857 | 0.87 | MCHR1 (0.51) | ATRACHE | |
| SCHEMBL4004985 | 0.87 | ATR (0.47) | ATRPRKDCATM | |
| SCHEMBL4008321 | 0.86 | ATR (0.55) | ATR | |
| SCHEMBL13956736 | 0.84 | EGFR (0.53) | ATRPRKDCATMEGFR | |
| SCHEMBL3928126 | 0.82 | MCHR1 (0.47) | — | |
| SCHEMBL4013295 | 0.80 | ATR (0.57) | ATRPRKDCATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007390-A2 | 2-PYRAZ INYLBENZ IMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | claimed |
| WO-2009007390-A2 | 2-PYRAZ INYLBENZ IMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |